• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biological psychiatry >T-type calcium channel antagonism decreases motivation for nicotine and blocks nicotine- and cue-induced reinstatement for a response previously reinforced with nicotine.
【24h】

T-type calcium channel antagonism decreases motivation for nicotine and blocks nicotine- and cue-induced reinstatement for a response previously reinforced with nicotine.

机译：T型钙通道拮抗作用降低了对尼古丁的动力，并阻止了尼古丁和提示诱导的恢复，从而恢复了先前由尼古丁增强的反应。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Recent evidence suggests an involvement of T-type calcium channels in the effects of drugs of abuse. METHODS: We examined the influence of the novel, potent, and selective T-type calcium channel antagonist [2-(4-cyclopropylphenyl)-N-((1R)-1-{5-[2,2,2-trifluoroethyl]oxo}pyridine-2-yl)eth yl]acetamide] (TTA-A2) (.3, 1, or 3 mg/kg) on motivation for nicotine, as measured by nicotine self-administration on a progressive ratio (PR) schedule, and nicotine- and cue-induced reinstatement for a response previously reinforced with nicotine delivery (n = 11 or 12 Long Evans rats/group). Furthermore, we examined the specificity of the TTA-A2 effects by characterizing its influence on PR responding for food (in the absence or presence of nicotine-potentiated responding), food- versus nicotine-induced cue-potentiated reinstatement for a response previously reinforced by food administration (n = 11 or 12 Wistar Hannover rats/group), and its ability to induce a conditioned place aversion. RESULTS: TTA-A2 dose-dependently decreased self-administration of nicotine on a PR schedule and the ability of both nicotine and a cue paired with nicotine to reinstate responding. The effects were specific for nicotine's incentive motivational properties, as TTA-A2 did not influence responding for food on a PR schedule but did attenuate the ability of nicotine to potentiate responding for food. Likewise, TTA-A2 did not alter food-induced cue-potentiated reinstatement for a response previously reinforced by food but did decrease nicotine-induced cue-potentiated reinstatement. Finally, TTA-A2 did not produce an aversive state, as indicated by a lack of ability to induce conditioned place aversion. CONCLUSIONS: These data suggest that T-type calcium channel antagonists have potential for alleviating nicotine addiction by selectively decreasing the incentive motivational properties of nicotine.
机译：背景：最近的证据表明，T型钙通道参与了滥用药物的作用。方法：我们检查了新型，有效和选择性的T型钙通道拮抗剂[2-（4-环丙基苯基）-N-（（1R）-1- {5- [2,2,2-三氟乙基] （TTA-A2）（0.3、1或3 mg / kg）对尼古丁的刺激作用，通过逐步比例（PR）的尼古丁自我给药来测量，以及尼古丁和提示诱导的恢复，以应对先前因尼古丁递送而增强的反应（n = 11或12只Long Evans大鼠/组）。此外，我们通过表征TTA-A2效应对PR反应对食物的响应（在不存在或存在尼古丁增强反应的情况下），食品对尼古丁引起的提示增强信号强度的影响来检验其特异性，该反应先前通过增强食物管理（n = 11或12只Wistar Hannover大鼠/组）及其诱导条件性位置反感的能力。结果：TTA-A2剂量依赖性地降低了PR时间表上尼古丁的自我给药以及尼古丁和提示与尼古丁配对恢复应答的能力。这种作用对尼古丁的激励动机特性是特有的，因为TTA-A2不会影响PR日程对食物的反应，但会减弱尼古丁增强食物反应的能力。同样，TTA-A2不会改变食物诱导的提示增强信号的恢复，但会降低尼古丁引起的提示增强信号的恢复。最后，TTA-A2没有产生厌恶状态，这是由于缺乏诱导条件性位置厌恶的能力所表明的。结论：这些数据表明，T型钙通道拮抗剂具有通过选择性降低尼古丁的激励动机特性来减轻尼古丁成瘾的潜力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号