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首页> 外文期刊>Biological psychiatry >Basolateral amygdala modulates terminal dopamine release in the nucleus accumbens and conditioned responding.
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Basolateral amygdala modulates terminal dopamine release in the nucleus accumbens and conditioned responding.

机译：基底外侧杏仁核调节伏伏核中的末端多巴胺释放并调节反应。

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BACKGROUND: Dopamine signaling in the nucleus accumbens (NAc) is essential for goal-directed behaviors and primarily arises from burst firing of ventral tegmental area neurons. However, the role of associative neural substrates such as the basolateral amygdala (BLA) in regulating phasic dopamine release in the NAc, particularly during reward seeking, remains unknown. METHODS: Male Sprague-Dawley rats learned to discriminate two cues: a discriminative stimulus (DS) that predicted sucrose reinforcement contingent upon a lever press and a nonassociated stimulus (NS) that predicted a second lever never reinforced with sucrose. Following training, a test session was completed in which NAc dopamine was measured using fast-scan cyclic voltammetry in conjunction with inactivation of the ipsilateral BLA (gamma-aminobutyric acid agonists; baclofen/muscimol) to determine the contribution of BLA activity to dopamine release in the NAc core during the task. RESULTS: Under vehicle conditions, DS and NS presentation elicited dopamine release within the NAc core. The DS evoked significantly more dopamine than the NS. Inactivation of the BLA selectively attenuated the magnitude of DS-evoked dopamine release, concurrent with an attenuation of DS-evoked conditioned approaches. Other behavioral responses (e.g., lever pressing) and dopamine release concomitant with those events were unaltered by BLA inactivation. Furthermore, neither ventral tegmental area electrically stimulated dopamine release nor the probability of high concentration dopamine release events was altered following BLA inactivation. CONCLUSIONS: These results demonstrate that the BLA terminally modulates dopamine signals within the NAc core under specific, behaviorally relevant conditions, illustrating a functional mechanism by which the BLA selectively facilitates responding to motivationally salient environmental stimuli.
机译：背景：伏隔核（NAc）中的多巴胺信号传导对于定向行为至关重要，并且主要源于腹侧被盖区神经元的突发放电。但是，相关的神经基质，如基底外侧杏仁核（BLA）在调节NAc中的阶段性多巴胺释放方面，尤其是在寻求奖励时，其作用尚不清楚。方法：雄性Sprague-Dawley大鼠学会了辨别两种线索：一种预测性刺激（DS）预测蔗糖的增强取决于杠杆的压迫，另一种非相关性刺激（NS）预测第二项杠杆从未被蔗糖增强的抗性。训练后，完成了一个测试环节，其中使用快速扫描循环伏安法结合同侧BLA（γ-氨基丁酸激动剂;巴氯芬/麝香酚）的失活来测量NAc多巴胺，以确定BLA活性对多巴胺释放的影响。任务期间的NAc核心。结果：在车辆条件下，DS和NS呈递引起NAc核心内的多巴胺释放。 DS引起的多巴胺明显高于NS。 BLA的失活选择性地减弱了DS诱发的多巴胺释放的幅度，同时减弱了DS诱发的条件疗法。 BLA灭活并没有改变与这些事件同时发生的其他行为反应（例如，按下操纵杆）和多巴胺释放。此外，在BLA灭活后，腹侧被盖区的电刺激多巴胺释放和高浓度多巴胺释放事件的可能性均未改变。结论：这些结果表明，BLA在特定的，行为相关的条件下最终调节NAc核心内的多巴胺信号，说明了BLA选择性地促进对动机性环境显着刺激作出反应的功能机制。

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