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首页> 外文期刊>The Journal of Allergy and Clinical Immunology >Fungal extracellular polysaccharides in house dust as a marker for exposure to fungi: relations with culturable fungi, reported home dampness, and respiratory symptoms.
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Fungal extracellular polysaccharides in house dust as a marker for exposure to fungi: relations with culturable fungi, reported home dampness, and respiratory symptoms.

机译：室内灰尘中的真菌细胞外多糖作为暴露于真菌的标志：与可培养真菌的关系，报告的家庭潮湿和呼吸道症状。

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BACKGROUND: Epidemiologic studies have demonstrated an association between indoor fungal growth and respiratory symptoms. However, in only a few studies was fungal exposure actually measured. OBJECTIVE: The purpose of this study was to evaluate the measurement by enzyme immunoassay of extracellular polysaccharides of Aspergillus and Penicillium species (EPS-Asp/Pen ) in house dust as a marker for fungal exposure and to study the relations between EPS-Asp/Pen levels and home dampness and respiratory symptoms in children. METHODS: Extracts of house dust samples from bedroom and living room floors and mattresses from homes of 31 children with chronic respiratory symptoms and 29 children with no chronic respiratory symptoms were analyzed for EPS-Asp/Pen. RESULTS: EPS-Asp/Pen were readily detectable (40 to 46,513 nanogram equivalent/g dust) in 161 house dust extracts, with highest concentrations in living room floor dust. EPS-Asp/Pen levels were 2 to 3 times higher on carpeted floors than on smooth floors. EPS-Asp/Pen were significantly correlated with total culturable fungi (r = 0.3 to 0.5) and with house dust mite allergens (r = 0.3 to 0.5). EPS-Asp/Pen levels in living room floor dust were positively associated with occupant-reported home dampness. This was not observed for EPS-Asp/Pen in bedroom floor and mattress dust. EPS-Asp/Pen levels in living room floor dust were positively associated with respiratory symptoms. EPS-Asp/Pen in bedroom floor and mattress dust showed a reversed association with respiratory symptoms, possibly because of allergen-avoidance measures taken in the bedroom. CONCLUSION: The enzyme immunoassay for fungal EPS-Asp/Pen may be a useful method for exposure assessment of indoor fungi.
机译：背景：流行病学研究表明室内真菌的生长与呼吸系统症状之间存在关联。但是，只有少数研究实际测量了真菌暴露。目的：本研究的目的是通过酶免疫法测定室内灰尘中曲霉菌和青霉菌种的胞外多糖（EPS-Asp / Pen）作为真菌暴露的指标，并研究其与EPS-Asp / Pen之间的关系。水平，儿童潮湿和呼吸道症状。方法：分析了31例患有慢性呼吸道症状的儿童和29例无慢性呼吸道症状的儿童的卧室和客厅地板上的房屋灰尘样品以及来自家庭的床垫的提取物的EPS-Asp /笔。结果：161种房屋粉尘提取物中可轻易检测到EPS-Asp / Pen（40至46,513纳克当量/克粉尘），而客厅地板粉尘中的浓度最高。铺有地毯的地板的EPS-Asp / Pen水平比光滑地板高2至3倍。 EPS-Asp / Pen与可培养真菌总量（r = 0.3至0.5）和室内尘螨过敏原（r = 0.3至0.5）显着相关。客厅地板粉尘中的EPS-Asp / Pen水平与居住者报告的家庭潮湿度呈正相关。在卧室地板和床垫灰尘中未观察到EPS-Asp / Pen的情况。客厅地板灰尘中的EPS-Asp / Pen水平与呼吸道症状呈正相关。卧室地板上的EPS-Asp / Pen和笔和床垫灰尘显示出与呼吸道症状相反的关系，这可能是由于卧室采取了避免过敏原的措施。结论：真菌EPS-Asp / Pen酶免疫法可能是一种室内真菌暴露评估的有效方法。

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