Polymorphisms related to ORMDL3 are associated with asthma susceptibility, alterations in transcriptional regulation of ORMDL3, and changes in T(H)2 cytokine levels

Schedel Michaela; Michel Sven; Gaertner Vincent D.; Toncheva Antoaneta A.; Depner Martin; Binia Aristea; Schieck Maximilian; Rieger Marie T.; Klopp Norman; von Berg Andrea; Bufe Albrecht; Laub Otto; Rietschel Ernst; Heinzmann Andrea; Simma Burkard; Vogelberg Christian; Genuneit Jon; Illig Thomas; Kabesch Michael

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Polymorphisms related to ORMDL3 are associated with asthma susceptibility, alterations in transcriptional regulation of ORMDL3, and changes in T(H)2 cytokine levels

机译：与ORMDL3相关的多态性与哮喘易感性，ORMDL3转录调控的改变以及T（H）2细胞因子水平的变化有关

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Background: Chromosome 17q21, harboring the orosomucoid 1-like 3 (ORMDL3) gene, has been consistently associated with childhood asthma in genome-wide association studies.

机译：背景：在全基因组关联研究中，带有类类牙髓样1（3）基因（ORMDL3）的17q21染色体一直与儿童哮喘相关。

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《The Journal of Allergy and Clinical Immunology》 |2015年第4期|共25页
作者
Schedel Michaela; Michel Sven; Gaertner Vincent D.; Toncheva Antoaneta A.; Depner Martin; Binia Aristea; Schieck Maximilian; Rieger Marie T.; Klopp Norman; von Berg Andrea; Bufe Albrecht; Laub Otto; Rietschel Ernst; Heinzmann Andrea; Simma Burkard; Vogelberg Christian; Genuneit Jon; Illig Thomas; Kabesch Michael;
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正文语种 eng
中图分类医学免疫学;
关键词
Asthma; association study; polymorphism; ORMDL3; chromosome 17q21; promoter activity; T(H)2 cytokine; upstream stimulatory factor; transcriptional regulation;

机译：哮喘;联想研究;多态性;ORMDL3;染色体17q21;启动子活性;T（H）2细胞因子;上游刺激因子;转录调控;

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1. Polymorphisms related to ORMDL3 are associated with asthma susceptibility, alterations in transcriptional regulation of ORMDL3, and changes in T(H)2 cytokine levels [J] . Schedel Michaela, Michel Sven, Gaertner Vincent D., The Journal of Allergy and Clinical Immunology . 2015,第4期

机译：与ORMDL3相关的多态性与哮喘易感性，ORMDL3转录调控的改变以及T（H）2细胞因子水平的变化有关
2. Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus [J] . Acevedo Nathalie, Reinius Lovisa E., Greco Dario, Human Molecular Genetics . 2015,第3期

机译：儿童哮喘的风险与GSDMB / ORMDL3位点的CpG位点多态性，区域DNA甲基化和mRNA水平有关
3. Investigating the Association of Orosomucoid 1-like 3 (ORMDL3) Gene Polymorphism (rs12603332) with Susceptibility to Allergic Asthma in Iranian Northwestern Azeri Population [J] . Iranian Journal Of Allergy, Asthma and Immunology . 2018,第6期

机译：调查伊朗西北部阿塞拜疆族人群的类牙髓样1（3）（ORMDL3）基因多态性（rs12603332）与过敏性哮喘的易感性
4. ANEMIA OF CHRONIC DISEASE IN PATIENTS WITH AA-AMYLOIDOSIS: RELATIONSHIP TO POLYMORPHISMS OF THE INTERLEUKIN-1 GENE COMPLEX AND CIRCULATING CYTOKINE LEVELS [C] . C.P.J-Maury, M.Liljestrdm, K.Laiho, International Symposium on Amyloidosis . 2005

机译：AA - 淀粉样症患者患者贫血患者：与白细胞介素-1基因复合物的多态性关系和循环细胞因子水平的关系
5. Regulation of CD8+ T Cell Differentiation by Cytokines and T-box Transcription Factors [D] . Reiser, John W. 2019

机译：细胞因子和T型箱转录因子调节CD8 + T细胞分化
6. Risk of childhood asthma is associated with CpG-site polymorphisms regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus [O] . Nathalie Acevedo, Lovisa E. Reinius, Dario Greco, -1

机译：儿童哮喘的风险与GSDMB / ORMDL3位点的CpG位点多态性区域DNA甲基化和mRNA水平有关
7. Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus [O] . Acevedo, Nathalie, Reinius, Lovisa E., Greco, Dario, 2015

机译：儿童哮喘的风险与GSDMB / ORMDL3位点的CpG位点多态性，区域DNA甲基化和mRNA水平有关

Polymorphisms related to ORMDL3 are associated with asthma susceptibility, alterations in transcriptional regulation of ORMDL3, and changes in T(H)2 cytokine levels

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