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首页> 外文期刊>The Journal of Allergy and Clinical Immunology >Relationship of nasal carriage of Staphylococcus aureus to pathogenesis of perennial allergic rhinitis.
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Relationship of nasal carriage of Staphylococcus aureus to pathogenesis of perennial allergic rhinitis.

机译：鼻携带金黄色葡萄球菌与常年性变应性鼻炎发病机制的关系。

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BACKGROUND: Several studies have previously shown some factors that modify the pathogenesis of perennial allergic rhinitis (PAR). However, the association between bacterial colonization and PAR has not been well understood. OBJECTIVE: We sought to study the association between superantigen-producing Staphylococcus aureus and PAR. METHODS: S aureus colonization in the nasal cavity and its superantigen production were studied in 65 patients with PAR and 45 nonallergic control subjects. The nasal symptom scores of the patients were evaluated. Furthermore, we examined the response to staphylococcal enterotoxin B or toxic shock syndrome toxin 1 of peripheral blood lymphocytes from both patients and control subjects by measuring proliferative responses and production of cytokines (IFN-gamma, IL-4, and IL-5). RESULTS: The rate of nasal carriage of S aureus in the patients (44%) was significantly higher than that of the control subjects (20%, P <.01). Moreover, the rate of nasal carriage of superantigen-producing S aureus in the patients (22%) was significantly higher than that of the control subjects (6.7%, P <.05). The nasal symptom scores of the S aureus -positive patients were significantly higher than those of the S aureus -negative patients (P <.05), although there was no significant association between symptom scores and superantigen production. Peripheral blood lymphocytes from the patients showed significantly higher proliferative responses and were more likely to produce T(H2 )type cytokines in response to superantigens (P <.01), but the responses were not different among the patients with S aureus carriage and superantigen production. CONCLUSION: This study suggests that PAR leads to a higher carriage rate of S aureus, and nasal carriage of S aureus may aggravate PAR.
机译：背景：先前的一些研究表明，某些因素会改变常年性变应性鼻炎（PAR）的发病机理。但是，细菌定植与PAR之间的关联尚不十分清楚。目的：我们试图研究产生超抗原的金黄色葡萄球菌与PAR的关系。方法：对65例PAR患者和45例非过敏性对照受试者的鼻腔中金黄色葡萄球菌定植及其超抗原产生进行了研究。评价患者的鼻症状评分。此外，我们通过测量增殖反应和细胞因子（IFN-γ，IL-4和IL-5）的产生，检查了来自患者和对照对象的外周血淋巴细胞对葡萄球菌肠毒素B或中毒性休克综合征毒素1的反应。结果：患者的金黄色葡萄球菌鼻腔转运率（44％）显着高于对照组（20％，P <.01）。此外，患者中产生超抗原的金黄色葡萄球菌的鼻腔运送率（22％）显着高于对照组（6.7％，P <.05）。金黄色葡萄球菌阳性患者的鼻症状评分显着高于金黄色葡萄球菌阴性患者的鼻症状评分（P <.05），尽管症状评分和超抗原产生之间没有显着相关性。患者的外周血淋巴细胞显示出明显更高的增殖反应，并且更有可能对超抗原产生T（H2）型细胞因子（P <.01），但在金黄色葡萄球菌携带和超抗原产生的患者中，反应无差异。结论：这项研究表明，PAR导致金黄色葡萄球菌的更高的携带率，而鼻腔运送金黄色葡萄球菌可能加重PAR。

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