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首页> 外文期刊>Biological psychiatry >Right orbitofrontal corticolimbic and left corticocortical white matter connectivity differentiate bipolar and unipolar depression.
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Right orbitofrontal corticolimbic and left corticocortical white matter connectivity differentiate bipolar and unipolar depression.

机译：右眶额皮质白质和左皮质白质连通性区分双相和单相抑郁症。

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OBJECTIVES: The absence of pathophysiologically relevant diagnostic markers of bipolar disorder (BD) leads to its frequent misdiagnosis as unipolar depression (UD). We aimed to determine whether whole brain white matter connectivity differentiated BD from UD depression. METHODS: We employed a three-way analysis of covariance, covarying for age, to examine whole brain fractional anisotropy (FA), and corresponding longitudinal and radial diffusivity, in currently depressed adults: 15 with BD-type I (mean age 36.3 years, SD 12.0 years), 16 with recurrent UD (mean age 32.3 years, SD 10.0 years), and 24 healthy control adults (HC) (mean age 29.5 years, SD 9.43 years). Depressed groups did not differ in depression severity, age of illness onset, and illness duration. RESULTS: There was a main effect of group in left superior and inferior longitudinal fasciculi (SLF and ILF) (all F > or = 9.8; p < or = .05, corrected). Whole brain post hoc analyses (all t > or = 4.2; p < or = .05, corrected) revealed decreased FA in left SLF in BD, versus UD adults in inferior temporal cortex and, versus HC, in primary sensory cortex (associated with increased radial and decreased longitudinal diffusivity, respectively); and decreased FA in left ILF in UD adults versus HC. A main effect of group in right uncinate fasciculus (in orbitofrontal cortex) just failed to meet significance in all participants but was present in women. Post hoc analyses revealed decreased right uncinate fasciculus FA in all and in women, BD versus HC. CONCLUSIONS: White matter FA in left occipitotemporal and primary sensory regions supporting visuospatial and sensory processing differentiates BD from UD depression. Abnormally reduced FA in right fronto-temporal regions supporting mood regulation, might underlie predisposition to depression in BD. These measures might help differentiate pathophysiologic processes of BD versus UD depression.
机译：目的：缺乏双相情感障碍（BD）的病理生理相关诊断标志物，导致其常被误诊为单相抑郁（UD）。我们旨在确定全脑白质连通性是否使BD与UD抑郁区分开。方法：我们采用三项协方差分析（随年龄变化）来检查当前抑郁成年人的全脑分数各向异性（FA）以及相应的纵向和径向弥散性：15例BD型I（平均年龄36.3岁， SD 12.0岁），16例复发性UD（平均年龄32.3岁，SD 10.0岁）和24名健康对照成年人（HC）（平均年龄29.5岁，SD 9.43岁）。抑郁组在抑郁的严重程度，发病年龄和病程方面没有差异。结果：该组对左上，下纵筋膜（SLF和ILF）有主要作用（所有F>或= 9.8; p <或= .05，已校正）。全脑事后分析（所有t>或= 4.2; p <或= .05，已校正）显示，BD左SLF中的FA降低，颞下皮质相对于UD成人，而初级感觉皮质（与HC相关）分别增加了径向扩散率和纵向扩散率）与HC相比，UD成人左ILF的FA降低。该组在右束状筋膜（眶额皮层）中的主要作用在所有参与者中均未达到显着水平，但在女性中存在。事后分析显示，BD与HC相比，所有患者和女性右结膜筋膜FA均减少。结论：左枕颞和主要感觉区的白质FA支持视觉空间和感觉处理，从而使BD与UD抑郁区分开来。支持情绪调节的右额颞区的FA异常降低，可能是BD抑郁症的诱因。这些措施可能有助于区分BD与UD抑郁症的病理生理过程。

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