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首页> 外文期刊>Biological psychiatry >Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner.
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Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner.

机译：Ghrelin以依赖于orexin的方式增加高脂饮食的奖励价值。

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BACKGROUND: Ghrelin is a potent orexigenic hormone that likely impacts eating via several mechanisms. Here, we hypothesized that ghrelin can regulate extra homeostatic, hedonic aspects of eating behavior. METHODS: In the current study, we assessed the effects of different pharmacological, physiological, and genetic models of increased ghrelin and/or ghrelin-signaling blockade on two classic behavioral tests of reward behavior: conditioned place preference (CPP) and operant conditioning. RESULTS: Using both CPP and operant conditioning, we found that ghrelin enhanced the rewarding value of high-fat diet (HFD) when administered to ad lib-fed mice. Conversely, wild-type mice treated with ghrelin receptor antagonist and ghrelin receptor-null mice both failed to show CPP to HFD normally observed under calorie restriction. Interestingly, neither pharmacologic nor genetic blockade of ghrelin signaling inhibited the body weight homeostasis-related, compensatory hyperphagia associated with chronic calorie restriction. Also, ghrelin's effects on HFD reward were blocked in orexin-deficient mice and wild-type mice treated with an orexin 1 receptor antagonist. CONCLUSIONS: Our results demonstrate an obligatory role for ghrelin in certain rewarding aspects of eating that is separate from eating associated with body weight homeostasis and that requires the presence of intact orexin signaling.
机译：背景：Ghrelin是一种强力的致食激素，可能通过多种机制影响进食。在这里，我们假设ghrelin可以调节进食行为的其他稳态，享乐性方面。方法：在当前的研究中，我们评估了生长激素释放肽和/或生长素释放肽信号传导阻滞增加的不同药理，生理和遗传模型对奖励行为的两种经典行为测试的影响：有条件的场所偏好（CPP）和操作者条件。结果：我们同时使用CPP和操作条件调节，发现生长素释放肽对随意喂养的小鼠给药后，可提高高脂饮食（HFD）的奖励价值。相反，用生长素释放肽受体拮抗剂治疗的野生型小鼠和生长激素释放肽受体无效的小鼠均未显示出在热量限制下正常观察到的CPP至HFD。有趣的是，ghrelin信号的药理或遗传阻滞作用均不能抑制与体重受限有关的体重稳态，代偿性食欲过高。同样，在用orexin 1受体拮抗剂治疗的orexin缺乏小鼠和野生型小鼠中，ghrelin对HFD奖励的作用被阻断。结论：我们的研究结果表明生长激素释放肽在饮食的某些奖励方面具有强制性作用，这种作用与与体重稳态相关的饮食分开，并且需要完整的orexin信号传导。

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