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首页> 外文期刊>Biological psychiatry >N-methyl-D-aspartic acid receptors on striatal neurons are essential for cocaine cue reactivity in mice.
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N-methyl-D-aspartic acid receptors on striatal neurons are essential for cocaine cue reactivity in mice.

机译：纹状体神经元上的N-甲基-D-天冬氨酸受体对于可卡因提示反应性至关重要。

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BACKGROUND: Environmental cues associated with cocaine evoke craving and seeking. This process, termed cue reactivity, is a critical element of cocaine addiction. Although glutamatergic neurotransmission has been implicated in this effect of cocaine, the precise subtype and localization in the brain of the glutamatergic receptor critical for cocaine cue reactivity is not well-understood. METHODS: We used a conditional N-methyl-D-aspartic acid receptor (NMDAR) knockout mouse whose NMDAR gene was deleted by Cre expression restricted to striatal neurons. To evaluate the role of NMDAR in cocaine cue reactivity, conditional knockout mice and control mice (n = 5-8/group) were conditioned for place preference with cocaine (5 and 10 mg/kg SC) for 3 days. Their subsequent place preference was examined in a drug-free state. RESULTS: Although control mice developed cocaine conditioned place preference, mice deficient for NMDAR on striatal neurons failed to develop conditioned place preference. CONCLUSIONS: The NMDAR on striatal neurons is essential for the development of cocaine cue reactivity in the place conditioning paradigm. Our finding identifies a brain region whose constitutive NMDAR level serves as a determinant for susceptibility to this aspect of cocaine addiction.
机译：背景：与可卡因有关的环境暗示引起人们的渴望和寻求。此过程称为提示反应性，是可卡因成瘾的关键因素。尽管可卡因的这种作用牵涉到谷氨酸能神经传递，但是对于可卡因线索反应性至关重要的谷氨酸能受体的精确亚型和在脑中的定位仍未得到很好的理解。方法：我们使用了条件性N-甲基-D-天冬氨酸受体（NMDAR）基因敲除小鼠，其NMDAR基因因限于纹状体神经元的Cre表达而缺失。为了评估NMDAR在可卡因提示反应性中的作用，将条件基因敲除小鼠和对照小鼠（n = 5-8 /组）用可卡因（5和10 mg / kg SC）进行位置偏好3天。在无毒品的情况下检查了他们随后的位置偏好。结果：尽管对照小鼠发展了可卡因条件位置偏爱，但是纹状体神经元上缺乏NMDAR的小鼠却未能发展条件位置偏爱。结论：纹状体神经元上的NMDAR对于在场所条件范式中可卡因提示反应性的发展至关重要。我们的发现确定了一个大脑区域，其组成性NMDAR水平可作为可卡因成瘾这一方面敏感性的决定因素。

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