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首页> 外文期刊>The Journal of Allergy and Clinical Immunology >Relationships among environmental exposures, cord blood cytokine responses, allergy, and wheeze at 1 year of age in an inner-city birth cohort (Urban Environment and Childhood Asthma study).
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Relationships among environmental exposures, cord blood cytokine responses, allergy, and wheeze at 1 year of age in an inner-city birth cohort (Urban Environment and Childhood Asthma study).

机译：在一个城市出生队列中，环境暴露，脐血细胞因子反应，过敏和1岁时的喘息之间的关系（城市环境和儿童哮喘研究）。

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BACKGROUND: The Urban Environment and Childhood Asthma study was established to investigate the immunologic and environmental causes of asthma in inner-city children. OBJECTIVE: We sought to evaluate potential atopic outcomes in the first 12 months and their relationships to environmental exposures and immune development. METHODS: A birth cohort of 560 children with at least 1 parent with allergy or asthma was established in Baltimore, Boston, New York, and St Louis. Wheezing is assessed every 3 months, allergen-specific IgE yearly, and mononuclear cell cytokine responses at birth and yearly; environmental assessments include dust allergen and endotoxin, maternal stress, and indoor nicotine and nitrogen dioxide levels. RESULTS: Key outcomes in the first year include wheeze in 49%, 2 or more episodes of wheeze in 23%, eczema in 30%, and detectable IgE to milk, egg, and/or peanut in 32% and to cockroach in 4%. Household dust revealed levels of greater than 2 mug/g to cockroach in 40%, mite in 19%, cat in 25%, and mouse in 29%, and 66% of homes housed at least 1 smoker. Positive associations were detected between multiple wheeze and cotinine levels, maternal stress, and maternal depression, whereas cytokine responses to a variety of innate, adaptive, and mitogenic stimuli were inversely related to eczema. CONCLUSIONS: This high-risk cohort of inner-city infants is exhibiting high rates of wheeze, eczema, and allergic sensitization. Low cytokine responses at birth might be a risk factor for eczema, whereas a variety of adverse environmental exposures contribute to the risk of wheezing in infancy. These findings provide evidence of specificity in the interactions between immune development, environmental exposures, and the development of early features that might predict future asthma.
机译：背景：建立城市环境与儿童哮喘研究的目的是调查内城区儿童哮喘的免疫学和环境原因。目的：我们试图评估前12个月的潜在特应性转归及其与环境暴露和免疫发展的关系。方法：在巴尔的摩，波士顿，纽约和圣路易斯建立了560名儿童的出生队列，其中至少有1名父母患有过敏或哮喘。每3个月评估一次喘息，每年评估变应原特异性IgE，并在出生和每年评估一次单核细胞细胞因子反应;环境评估包括灰尘过敏原和内毒素，孕产妇压力以及室内尼古丁和二氧化氮水平。结果：第一年的主要结局包括49％的喘息，23％的2次或两次以上的喘息，30％的湿疹以及32％的牛奶，鸡蛋和/或花生和4％的蟑螂可检测到的IgE 。家庭灰尘显示蟑螂中40％以上，蟑螂中19％，猫中25％，老鼠中29％，29％，其中至少有1名吸烟者的水平超过2杯/克。在多种喘息和可替宁水平，母体压力和母体抑郁之间检测到正相关，而细胞因子对多种先天性，适应性和促有丝分裂刺激的反应与湿疹成反比。结论：这个高风险的内城区婴儿队列表现出较高的喘鸣，湿疹和过敏性致敏率。出生时细胞因子反应低可能是湿疹的危险因素，而各种不利的环境暴露也会导致婴儿患喘息的风险。这些发现提供了免疫发展，环境暴露以及可能预测未来哮喘的早期特征之间相互作用的特异性证据。

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