Duple stabilizing effect and nuclease resistant property of novel oligonucleotides containing C-2 branched polyamine-bearing deoxyinosine derivative

Kazuo Shinozuka; Masaaki Onodera; Hiroshi Ikeda; Hiroaki Sawai

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Duple stabilizing effect and nuclease resistant property of novel oligonucleotides containing C-2 branched polyamine-bearing deoxyinosine derivative

机译：含C-2支链多胺脱氧肌苷衍生物的新型寡核苷酸的双重稳定作用和抗核酸酶性能

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摘要

Novel oligodeoxyribonucleotides containing a C-2 branched polyamine-bearing deoxyinosine moiety at either inside-region or the 5'-terminus of the sequence exhibited enhanced nuclease resistant property. Among them, only the oligomers having the modified deoxyinosine residue at inside-region brought about duplex stabilizing effect upon mixing with the complements.

机译：在序列的内部区域或5'-末端含有带有C-2支链多胺的脱氧肌苷部分的新型寡脱氧核糖核苷酸表现出增强的核酸酶抗性。其中，仅在内部区域具有修饰的脱氧肌苷残基的低聚物在与补体混合时具有双链体稳定作用。

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《Chemistry Letters》 |2002年第2期|共2页
作者
Kazuo Shinozuka; Masaaki Onodera; Hiroshi Ikeda; Hiroaki Sawai;
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正文语种 eng
中图分类化学;化学工业;
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1. Duple stabilizing effect and nuclease resistant property of novel oligonucleotides containing C-2 branched polyamine-bearing deoxyinosine derivative [J] . Kazuo Shinozuka, Masaaki Onodera, Hiroshi Ikeda, Chemistry Letters . 2002,第2期

机译：含C-2支链多胺脱氧肌苷衍生物的新型寡核苷酸的双重稳定作用和抗核酸酶性能
2. Synthesis and Triple-Helix-Stabilization Properties of Branched Oligonucleotides Carrying 8-Aminoadenine Moieties [J] . Anna Avino, Marta G.Grimau, Miriam Frieden, Helvetica chimica acta . 2004,第2期

机译：带有8-氨基腺嘌呤部分的支链寡核苷酸的合成和三螺旋稳定化性质
3. SYNTHESIS AND BIOPHYSICAL AND BIOLOGICAL PROPERTIES OF OLIGONUCLEOTIDES CONTAINING 2-AZA-2'-DEOXYINOSINE [J] . Acedo M., Eritja R., Declercq E. The Journal of Organic Chemistry . 1995,第20期

机译：含2-AZA-2'-脱氧肌苷的寡核苷酸的合成及其生物物理特性
4. New Nuclease-Resistant Immunostimulatory Phosphodiester-based Oligonucleotides for Immune Therapies [C] . Tomohiko Yamazaki, Wenjun Meng, Nobutaka Hanagata World biomaterials congress . 2012

机译：新的抗核酸酶的免疫刺激性基于磷酸二酯的寡核苷酸用于免疫治疗。
5. Nuclease-resistant c-di-AMP derivatives that differentially recognize RNA and protein receptors. [D] . Meehan, Robert Eric. 2015

机译：耐核酸酶的c-di-AMP衍生物可区别地识别RNA和蛋白质受体。
6. Studies on the base pairing properties of deoxyinosine by solid phase hybridisation to oligonucleotides. [O] . S C Case-Green, E M Southern 1994

机译：通过与寡核苷酸的固相杂交研究脱氧肌苷的碱基配对特性。
7. Synthesis and Triple-Helix-Stabilization Properties of Branched Oligonucleotides Carrying 8-Aminoadenine Moieties [O] . Aviñó, Anna, Grimau, Marta G., Frieden, Miriam, 2004

机译：带有8-氨基腺嘌呤部分的支链寡核苷酸的合成和三螺旋稳定化性质
8. Evaluation of a Nuclease-Resistant Derivative of Poly(I) Poly(C) (Poly(ICLC)) as a Radioprotective Agent 1, 2. [R] . Baze, W. B., Lvovsky, E., Higbee, G. A., 1978

机译：评价聚（I）聚（C）（聚（ICLC））的核酸酶抗性衍生物作为辐射防护剂1,2。

Duple stabilizing effect and nuclease resistant property of novel oligonucleotides containing C-2 branched polyamine-bearing deoxyinosine derivative

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