...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Allergy and Clinical Immunology >A new criterion by which to discriminate between patients with moderate allergic rhinitis and patients with severe allergic rhinitis based on the Allergic Rhinitis and its Impact on Asthma severity items.
【24h】

A new criterion by which to discriminate between patients with moderate allergic rhinitis and patients with severe allergic rhinitis based on the Allergic Rhinitis and its Impact on Asthma severity items.

机译：一种基于变应性鼻炎及其对哮喘严重程度影响的区分中度变应性鼻炎和重度变应性鼻炎的新标准。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Allergic Rhinitis and its Impact on Asthma (ARIA) differentiates mild from moderate/severe patients on the basis of 4 severity items. The high prevalence of moderate/severe patients suggests the need to differentiate between them. OBJECTIVES: To identify the categorization that maximizes discrimination between moderate and severe allergic rhinitis (AR) by using ARIA guidelines. METHODS: Observational, cross-sectional study. Clinical characteristics, nasal symptoms (Total Symptom Score 4), and health-related quality of life (HRQL; Rhinoconjunctivitis Quality of Life Questionnaire and Short Form 12) were assessed. The association of severity items (sleep, daily activities/sport, work/school, and troublesome symptoms) with symptoms and HRQL was analyzed using linear regression models. ANOVA and effect sizes were used to assess differences in symptoms and HRQL among groups defined by the number of affected ARIA items. RESULTS: Nontreated patients (N = 141) with moderate/severe AR were studied. All severity items showed a similar independent association with symptoms and HRQL scores, and there were no interaction effects, indicating that categorization of patients into moderate and severe could be based only on the number of items affected. Effect sizes were highest between patients with 4 affected ARIA items and those with 3, 2, or 1 affected item (effect sizes greater than 0.8 in all comparisons using Rhinoconjunctivitis Quality of Life Questionnaire and Short Form 12 Physical Composite Summary, and greater than 0.5 using the Total Symptom Score 4; P < .001). CONCLUSION: Using ARIA severity items, the criterion that best discriminates AR severity is considering moderate those with 1 to 3 affected items and severe those with 4. CLINICAL IMPLICATIONS: Discrimination between patients with moderate and severe AR should help to obtain homogeneous populations for both research and clinical purposes.
机译：背景：过敏性鼻炎及其对哮喘的影响（ARIA）根据4个严重程度项目将轻度患者与中度/重度患者区分开。中度/重度患者的高患病率表明需要区分他们。目的：通过使用ARIA指南，确定能最大程度区分中度和重度过敏性鼻炎（AR）的分类。方法：观察性横断面研究。评估了临床特征，鼻部症状（症状总分4）和健康相关的生活质量（HRQL;鼻结膜炎生活质量问卷和简表12）。使用线性回归模型分析了严重程度项目（睡眠，日常活动/运动，工作/学校和麻烦的症状）与症状和HRQL的关联。方差分析和效应量用于评估由受影响的ARIA项目数定义的各组之间症状和HRQL的差异。结果：研究了未经治疗的中度/重度AR患者（N = 141）。所有严重程度项目均显示出与症状和HRQL评分相似的独立关联，并且没有交互作用，这表明将患者分为中度和重度只能基于受影响的项目数。在有4种受累ARIA项目的患者和有3、2或1种受累项目的患者中，效果大小最高（使用鼻结膜炎生活质量问卷和简短表格12物理综合摘要进行的所有比较中，效果大小均大于0.8，而使用RIA则小于0.5）总症状评分4; P <.001）。结论：使用ARIA严重程度项目，最能区分AR严重程度的标准是考虑患有1至3个受影响项目的中度患者和具有4严重程度的患者。临床意义：中度和重度AR患者之间的区别应有助于为两个研究获得同质人群和临床目的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号