Psilocybin-Induced Decrease in Amygdala Reactivity Correlates with Enhanced Positive Mood in Healthy Volunteers

Kraehenmann Rainer; Preller Katrin H.; Scheidegger Milan; Pokorny Thomas; Bosch Oliver G.; Seifritz Erich; Vollenweider Franz X.

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Psilocybin-Induced Decrease in Amygdala Reactivity Correlates with Enhanced Positive Mood in Healthy Volunteers

机译：扁桃体素诱导的杏仁核反应性降低与健康志愿者的积极情绪增强相关

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BACKGROUND: The amygdala is a key structure in serotonergic emotion-processing circuits. In healthy volunteers, acute administration of the serotonin 1A/2A/2C receptor agonist psilocybin reduces neural responses to negative stimuli and induces mood changes toward positive states. However, it is little-known whether psilocybin reduces amygdala reactivity to negative stimuli and whether any change in amygdala reactivity is related to mood change.

机译：背景：杏仁核是血清素能情绪处理电路中的关键结构。在健康的志愿者中，血清素1A / 2A / 2C受体激动剂psilocybin的急性给药可减少对阴性刺激的神经反应，并导致情绪向阳性状态变化。然而，鲜为人知的是鹦鹉螺菌素是否会降低杏仁核对阴性刺激的反应性，杏仁核反应性的任何变化是否与情绪变化有关。

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《Biological psychiatry》 |2015年第8期|共10页
作者
Kraehenmann Rainer; Preller Katrin H.; Scheidegger Milan; Pokorny Thomas; Bosch Oliver G.; Seifritz Erich; Vollenweider Franz X.;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Amygdala; Depression; Emotion; fMRI; Psilocybin; Serotonin;

机译：杏仁核;抑郁;情绪;功能磁共振成像;肉胞素;血清素;

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1. Psilocybin-Induced Decrease in Amygdala Reactivity Correlates with Enhanced Positive Mood in Healthy Volunteers [J] . Kraehenmann Rainer, Preller Katrin H., Scheidegger Milan, Biological psychiatry . 2015,第8期

机译：扁桃体素诱导的杏仁核反应性降低与健康志愿者的积极情绪增强相关
2. Probing the association between serotonin-1A autoreceptor binding and amygdala reactivity in healthy volunteers [J] . Kranz Georg S., Hahn Andreas, Kraus Christoph, NeuroImage . 2018,第期

机译：探讨血清素-1A自身青贮结合与健康志愿者的杏仁菌反应性的关系
3. Emotional traits predict individual differences in amphetamine-induced positive mood in healthy volunteers [J] . Kirkpatrick Matthew G., Goldenson Nicholas I., Kapadia Nahel, Psychopharmacology . 2016,第1期

机译：情绪特征预测健康志愿者中苯丙胺诱导的积极情绪的个体差异
4. THE EFFECT OF CONTINUOUS POSITIVE AIRWAY PRESSURE ON TOTAL CEREBRAL BLOOD FLOW IN 23 HEALTHY AWAKE VOLUNTEERS [C] . Theresia I. Yiallourou, Celine Odier, Bryn A. Martin, ASME summer bioengineering conference;SBC2011 . 2012

机译：持续正气道压力对23名健康清醒志愿者的总脑血流量的影响
5. Cortical Thickness as a Predictor of Amygdala Reactivity in Healthy Adults. [D] . Pataky, Christina Erika. 2015

机译：皮质厚度作为健康成年人杏仁核反应性的预测指标。
6. Psilocybin-Induced Deficits in Automatic and Controlled Inhibition are Attenuated by Ketanserin in Healthy Human Volunteers [O] . Boris B Quednow, Michael Kometer, Mark A Geyer, 2012

机译：Ketanserin在健康的人类志愿者中减轻了菌丝素诱导的自动和受控抑制的缺陷。
7. Psilocybin-induced deficits in automatic and controlled inhibition are attenuated by ketanserin in healthy human volunteers [O] . Quednow, Boris B, Kometer, M, Geyer, M A, 2012

机译：酮色林在健康的人类志愿者中减轻了赛洛西宾诱导的自动和受控抑制缺陷。

Psilocybin-Induced Decrease in Amygdala Reactivity Correlates with Enhanced Positive Mood in Healthy Volunteers

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