Altered Glutamate Protein Co-Expression Network Topology Linked to Spine Loss in the Auditory Cortex of Schizophrenia

MacDonald Matthew L.; Ding Ying; Newman Jason; Hemby Scott; Penzes Peter; Lewis David A.; Yates Nathan A.; Sweet Robert A.

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Altered Glutamate Protein Co-Expression Network Topology Linked to Spine Loss in the Auditory Cortex of Schizophrenia

机译：改变的谷氨酸蛋白共表达网络拓扑结构与精神分裂症听觉皮层的脊柱丢失有关。

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BACKGROUND: Impaired glutamatergic signaling is believed to underlie auditory cortex pyramidal neuron dendritic spine loss and auditory symptoms in schizophrenia. Many schizophrenia risk loci converge on the synaptic glutamate signaling network. We therefore hypothesized that alterations in glutamate signaling protein expression and co-expression network features are present in schizophrenia.

机译：背景：谷氨酸能信号转导被认为是精神分裂症的听觉皮层锥体神经元树突棘丧失和听觉症状的基础。许多精神分裂症的风险基因座集中在突触谷氨酸信号网络上。因此，我们假设精神分裂症中存在谷氨酸信号蛋白表达和共表达网络特征的改变。

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《Biological psychiatry》 |2015年第11期|共10页
作者
MacDonald Matthew L.; Ding Ying; Newman Jason; Hemby Scott; Penzes Peter; Lewis David A.; Yates Nathan A.; Sweet Robert A.;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Auditory cortex; Glutamate; Postmortem; Proteomics; Schizophrenia; Spine;

机译：听觉皮层;谷氨酸;验尸;蛋白质组学;精神分裂症;脊柱;

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1. Altered Glutamate Protein Co-Expression Network Topology Linked to Spine Loss in the Auditory Cortex of Schizophrenia [J] . MacDonald Matthew L., Ding Ying, Newman Jason, Biological psychiatry . 2015,第11期

机译：改变的谷氨酸蛋白共表达网络拓扑结构与精神分裂症听觉皮层的脊柱丢失有关。
2. Apolipoprotein E*4 (APOE*4) Genotype Is Associated with Altered Levels of Glutamate Signaling Proteins and Synaptic Coexpression Networks in the Prefrontal Cortex in Mild to Moderate Alzheimer Disease [J] . Sweet Robert A., MacDonald Matthew L., Kirkwood Caitlin M., Molecular & cellular proteomics: MCP . 2016,第7期

机译：载脂蛋白E * 4（APOE * 4）基因型与轻度至中度阿尔茨海默病前额叶皮层中谷氨酸信号蛋白和突触共表达网络水平的改变有关
3. Reduced glutamate decarboxylase 65 protein within primary auditory cortex inhibitory boutons in schizophrenia [J] . MoyerC.E., DelevichK.M., FishK.N., Biological psychiatry . 2012,第9期

机译：减少精神分裂症初级听觉皮层抑制性按钮内的谷氨酸脱羧酶65蛋白
4. Analysis of membrane proteins from the prefrontal cortex in schizophrenia and control subjects [C] . Bruno Manadas, Jane English, David R Cotter, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：精神分裂症和对照对策中预偏移皮质中膜蛋白的分析
5. Rare loss of function mutations in N-methyl-Ｄ-aspartate glutamate receptors and their contributions to schizophrenia susceptibility [D] . Yu Yanjie, 余妍洁 2019

机译：N-甲基-D-天冬氨酸谷氨酸受体功能突变的罕见丧失及其对精神分裂症易感性的贡献
6. Altered Glutamate Protein Co-Expression Network Topology Linked to Spine Loss in the Auditory Cortex of Schizophrenia [O] . Matthew L. MacDonald, Ying Ding, Jason Newman, -1

机译：改变的谷氨酸蛋白共表达网络拓扑结构与精神分裂症听觉皮层的脊柱丢失有关。
7. Altered Glutamate Protein Co-Expression Network Topology Linked to Spine Loss in the Auditory Cortex of Schizophrenia [O] . Matthew L. MacDonald, Ying Ding, Jason Newman, 2015

机译：改变了谷氨酸蛋白联合表达网络拓扑，与精神分裂症的听觉皮层中的脊柱损失有关

Altered Glutamate Protein Co-Expression Network Topology Linked to Spine Loss in the Auditory Cortex of Schizophrenia

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