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首页> 外文期刊>Biological psychiatry >An Overview of Translationally Informed Treatments for Posttraumatic Stress Disorder: Animal Models of Pavlovian Fear Conditioning to Human Clinical Trials
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An Overview of Translationally Informed Treatments for Posttraumatic Stress Disorder: Animal Models of Pavlovian Fear Conditioning to Human Clinical Trials

机译：创伤后应激障碍的翻译信息治疗概述：帕夫洛夫恐惧条件人类实验动物模型。

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Posttraumatic stress disorder manifests after exposure to a traumatic event and is characterized by avoidanceumbing, intrusive symptoms and flashbacks, mood and cognitive disruptions, and hyperarousal/reactivity symptoms. These symptoms reflect dysregulation of the fear system likely caused by poor fear inhibition/extinction, increased generalization, and/or enhanced consolidation or acquisition of fear. These phenotypes can be modeled in animal subjects using Pavlovian fear conditioning, allowing investigation of the underlying neurobiology of normative and pathological fear. Preclinical studies reveal a number of neurotransmitter systems and circuits critical for aversive learning and memory that have informed the development of therapies used in human clinical trials. In this review, we discuss the evidence for a number of established and emerging pharmacotherapies and device-based treatments for posttraumatic stress disorder that have been developed via a bench to bedside translational model.
机译：创伤后应激障碍在暴露于创伤事件后即表现出来，其特征是回避/麻木，侵入性症状和倒叙，情绪和认知障碍以及过度兴奋/反应性症状。这些症状反映了恐惧系统的失调，这可能是由于恐惧抑制/消灭不良，泛化程度增加和/或恐惧的巩固或获得增强而引起的。可以使用巴甫洛夫式恐惧条件在动物受试者中对这些表型进行建模，从而可以研究规范性和病理性恐惧的潜在神经生物学。临床前研究揭示了许多对厌恶性学习和记忆至关重要的神经递质系统和回路，这些回路和回路为人类临床试验中疗法的发展提供了信息。在这篇综述中，我们讨论了许多已确立的和正在出现的药物治疗和基于器械的创伤后应激障碍治疗方法的证据，这些方法已经通过实验台到床旁的翻译模型得到了发展。

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