Attention-Deficit/Hyperactivity Disorder-like Phenotype in a Mouse Model with Impaired Actin Dynamics

Zimmermann Anika-Maria; Jene Tanja; Wolf Michael; Goerlich Andreas; Gurniak Christine B.; Sassoe-Pognetto Marco; Witke Walter; Friauf Eckhard; Rust Marco B.

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Attention-Deficit/Hyperactivity Disorder-like Phenotype in a Mouse Model with Impaired Actin Dynamics

机译：肌动蛋白动力学受损的小鼠模型中的注意力缺乏/多动障碍样表型。

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BACKGROUND: Actin depolymerizing proteins of the actin depolymerizing factor (ADF)/cofilin family are essential for actin dynamics, which is critical for synaptic function. Two ADF/cofilin family members, ADF and n-cofilin, are highly abundant in the brain, where they are present in excitatory synapses. Previous studies demonstrated the relevance of n-cofilin for postsynaptic plasticity, associative learning, and anxiety. These studies also suggested overlapping functions for ADF and n-cofilin.

机译：背景：肌动蛋白解聚因子（ADF）/ cofilin家族的肌动蛋白解聚蛋白对于肌动蛋白动力学至关重要，这对于突触功能至关重要。 ADF / cofilin家族的两个成员ADF和n-cofilin在大脑中高度丰富，存在于兴奋性突触中。先前的研究表明正cofilin与突触后可塑性，联想学习和焦虑的相关性。这些研究还表明ADF和正cofilin的功能重叠。

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《Biological psychiatry》 |2015年第2期|共12页
作者
Zimmermann Anika-Maria; Jene Tanja; Wolf Michael; Goerlich Andreas; Gurniak Christine B.; Sassoe-Pognetto Marco; Witke Walter; Friauf Eckhard; Rust Marco B.;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Actin dynamics; ADF; ADHD; Hyperactivity; Locomotion; n-cofilin;

机译：肌动蛋白动力学;ADF;ADHD;多动症;运动;n-cofilin;

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1. Attention-Deficit/Hyperactivity Disorder-like Phenotype in a Mouse Model with Impaired Actin Dynamics [J] . Zimmermann Anika-Maria, Jene Tanja, Wolf Michael, Biological psychiatry . 2015,第2期

机译：肌动蛋白动力学受损的小鼠模型中的注意力缺乏/多动障碍样表型。
2. Hyperactivity of Rac1-GTPase pathway impairs neuritogenesis of cortical neurons by altering actin dynamics [J] . Valentina Zamboni, Maria Armentano, Gaia Berto, Scientific reports. . 2018,第1期

机译：Rac1-GTPase途径的多动通过改变肌动蛋白动态来损害皮质神经元的神经发生
3. A single episode of stress during adolescence impairs short-term memory and increases risk behaviour in an animal model of attention-deficit/ hyperactivity disorder [J] . Raony Icaro, Geraldo Arnaldo, Pandolfo Pablo Behavioural processes . 2021,第1期

机译：青春期期间的一集应力损害短期记忆，增加了注意力缺陷/多动障碍动物模型中的风险行为
4. A Queueing Model for Attention-Deficit / Hyperactivity Disorder [C] . Myron HLYNKA, Lucia MANDZIUK World Multiconference on Systemics, Cybernetics and Informatics(SCI 2002) v.4: Mobile/Wireless Computing and Communication Systems I; 20020714-20020718; Orlando,FL; US . 2002

机译：注意缺陷/多动障碍的排队模型
5. Social Impairment of Adolescents with Attention-Deficit/Hyperactivity Disorder. [D] . Timmermanis, Victoria Kristine. 2015

机译：注意缺陷/多动症青少年的社会障碍。
6. Hyperactivity of Rac1-GTPase pathway impairs neuritogenesis of cortical neurons by altering actin dynamics [O] . Valentina Zamboni, Maria Armentano, Gaia Berto, -1

机译：Rac1-GTPase途径的过度活跃通过改变肌动蛋白的动力学来损害皮质神经元的神经形成
7. Association of Preterm Birth With Attention-Deficit/Hyperactivity Disorder-Like and Wider-Ranging Neurophysiological Impairments of Attention and Inhibition [O] . Rommel Anna-Sophie, James Sarah-Naomi, McLoughlin Gráinne, 2017

机译：早产与注意力缺陷/多动障碍和注意力和抑制范围较广的神经生理障碍的关联

Attention-Deficit/Hyperactivity Disorder-like Phenotype in a Mouse Model with Impaired Actin Dynamics

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