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Striatal Hypersensitivity During Stress in Remitted Individuals with Recurrent Depression

机译:缓解期复发性抑郁症患者应激期间的纹状体超敏反应

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BACKGROUND: Increased sensitivity to stress and dysfunctional reward processing are two primary characteristics of major depressive disorder (MDD) that may persist after remission. Preclinical work has established the pivotal role of the striatum in mediating both stress and reward responses. Human neuroimaging studies have corroborated these preclinical findings and highlighted striatal dysfunction in MDD in response to reward but have yet to investigate striatal function during stress, in particular in individuals with recurrent depression.
机译:背景:对压力的敏感性增加和奖励功能障碍是重度抑郁症(MDD)的两个主要特征,在缓解后可能会持续存在。临床前工作已经确定了纹状体在调节压力和奖赏反应中的关键作用。人类神经影像学研究证实了这些临床前发现,并强调了MDD的纹状体功能障碍以响应奖赏,但尚未研究应激期间的纹状体功能,特别是在复发性抑郁症患者中。

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