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首页> 外文期刊>The Journal of clinical dentistry. >Superiority of essential oils versus 0.075% CPC-containing mouthrinse: A two-week randomized clinical trial
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Superiority of essential oils versus 0.075% CPC-containing mouthrinse: A two-week randomized clinical trial

机译：精油相对于含0.075％CPC的漱口水的优越性：一项为期两周的随机临床试验

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Objective: The objective of this randomized, examiner-blind, parallel, controlled clinical study was to compare the antiplaque/antigingivitis efficacy of an essential oil-containing mouthrinse (EO) to a new 0.075% cetylpyridinium chloride mouthrinse (CPC) using a two-week experimental gingivitis model with a 5% hydroalcohol rinse serving as the negative control. ? Methods: After signing informed consents and completing baseline examinations, 185 subjects were randomized into three groups. Subjects began supervised/recorded rinsing with 20 ml of their assigned rinse for 30 seconds twice daily for two weeks, with no mechanical oral hygiene permitted. Baseline and two-week assessments were conducted as follows: Turesky Modification of the Quigley-Hein Plaque Index (PI), Modified Gingival Index (MGI), and the Gingival Bleeding Index (BI). Analysis of efficacy variables (i.e., mean PI, mean MGI, mean BI, and proportion of bleeding sites derived from the BI) was performed using a one-way analysis of covariance (ANCOVA). ? Results: Among the 182 subjects who completed the study, the EO rinse showed statistically significant reductions compared to the negative control within the range previously reported in this model; PI = 36.5% (p < 0.001) and MGI = 17.5% (p < 0.001). A 43.2% reduction in proportion of bleeding sites (p < 0.001) was demonstrated. Mean PI, MGI, and proportion of bleeding sites at two weeks were statistically significantly lower for the EO rinse compared to the CPC rinse (p < 0.001), showing 27.7%, 11.9%, and 30.0% reductions, respectively. ? Conclusion: An EO rinse provided superior antigingivitis/antiplaque efficacy compared to a 0.075% CPC rinse in this short-term clinical trial, and demonstrated efficacy within the range shown in previous studies using this model.
机译：目的：这项随机，平行，盲目，平行，对照的临床研究旨在比较含精油的漱口水（EO）与新型0.075％氯化十六烷基吡啶鎓漱口酶（CPC）的抗牙菌斑/抗牙龈炎的疗效，方法是使用两种每周实验性牙龈炎模型，以5％酒精冲洗作为阴性对照。 ？方法：在签署知情同意书并完成基线检查后，将185名受试者随机分为三组。受试者开始接受监督/记录的漂洗，每天两次，每次20毫升，漂洗30秒，持续两个星期，不允许机械口腔卫生。基线评估和两周评估如下：对Quigley-Hein斑块指数（PI），改良的牙龈指数（MGI）和牙龈出血指数（BI）进行Turesky修正。使用单方协方差分析（ANCOVA）对功效变量（即平均PI，平均MGI，平均BI和从BI得出的出血部位比例）进行分析。 ？结果：在完成该研究的182名受试者中，与该模型先前报道的阴性对照相比，EO漂洗显示出统计学上显着的减少; PI = 36.5％（p <0.001），MGI = 17.5％（p <0.001）。出血部位比例减少了43.2％（p <0.001）。与CPC冲洗相比，EO冲洗的平均PI，MGI和两周时出血部位的比例在统计学上显着降低（p <0.001），分别降低了27.7％，11.9％和30.0％。 ？结论：与该短期临床试验中0.075％的CPC冲洗液相比，EO冲洗液具有更好的抗牙龈炎/抗牙菌斑功效，并且在使用该模型的先前研究显示的范围内证明了其功效。

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