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Dental Caries: A Disease Which Remains a Public Health Concern in the 21st Century- The Exploration of a Breakthrough Technology for Caries Prevention

机译:龋齿:21世纪仍是公共卫生关注的疾病-突破性预防龋齿技术的探索

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Dental caries is a globally prevalent and ubiquitous oral health and public health concern.13 It can affect children at a very early age,46and will certainly afflict most individuals in adolescence and throughout adulthood.79Many decades of scientific research have greatly increased our understanding of dental caries, and the application of this knowledge has led to the successful implementation of fluoride-based therapies to help arrest caries development and progression.'"Nonetheless, dental caries remains a prevalent disease in society today.Dental caries is a multifactorial oral condition with a complex etiology.111 The interplay between dental plaque, constituents of the diet, and the host tissue, as well as genetic and environmental factors, have each increasingly been recognized for their importance in the pathogenesis of dental caries.101213 Some of the most important scientific concepts which have resulted from contemporary understanding include: 1) dental plaque is a complex oral biofilm which displays unique behavior that is quite different from the behavior of its constituent planktonic species;11416 2) dental caries results from an ecological shift in dental plaque, from a healthy to a pathogenic flora;1217 3) dental caries is a process, not an endpoint, and up to the point of cavitation this process may be arrested or reversed;1819 and 4) the caries process is a dynamic balance between pathological and protective factors which can progress if the pathological factors are dominant, and be reversed if the protective factors prevail.2021
机译:龋齿是全球范围内普遍存在的口腔健康和公共卫生问题。13它可能会影响儿童,年龄很小,46而且肯定会困扰大多数人的青春期和整个成年期。79数十年来的科学研究极大地增进了我们对牙科的了解龋齿,这种知识的应用已成功实施了基于氟化物的疗法,以帮助遏制龋齿的发展和进展。”“尽管如此,龋齿仍是当今社会上的一种普遍疾病。牙科龋齿是一种多因素口腔疾病,伴有龋齿。 111牙菌斑,饮食成分和宿主组织之间的相互作用以及遗传和环境因素,都因其在龋齿发病机理中的重要性而日益得到认可。101213一些最重要的科学方法当代理解所产生的概念包括:1)牙菌斑很复杂口腔生物膜,其独特行为与其构成的浮游物种的行为完全不同; 11416 2)龋齿是由于牙菌斑从生态系统向健康致病菌区系的生态转变所致; 1217 3)龋齿是一个过程,并非终点,直到气穴为止,该过程可能会被阻止或逆转; 1819和4)龋齿过程是病理因素和保护因素之间的动态平衡,如果病理因素占优势,则可以进展,而如果龋齿是保护性因素则可以逆转。保护因素占主导地位2021

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