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首页> 外文期刊>The Journal of clinical dentistry. >Evaluation of a Dentifrice Containing 8% Arginine, Calcium Carbonate, and Sodium Monofluorophosphate to Repair Acid-Softened Enamel Using an Intra-Oral Remineralization Model
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Evaluation of a Dentifrice Containing 8% Arginine, Calcium Carbonate, and Sodium Monofluorophosphate to Repair Acid-Softened Enamel Using an Intra-Oral Remineralization Model

机译：口腔内矿化模型评估含8％精氨酸，碳酸钙和一氟磷酸钠的牙膏修复酸软化牙釉质

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Objective: An intra-oral remineralization study was conducted to compare the ability of a dentifrice containing 8% arginine and calcium carbonate (Pro-Argin? Technology), and 1450 ppm fluoride as sodium monofluorophosphate (MFP) to remineralize acid-softened bovine enamel specimens compared to a silica-based dentifrice with 1450 ppm fluoride as MFP. Methods: The intra-oral clinical study employed a double blind, two-treatment, crossover design, and used an upper palatal retainer to expose the enamel specimens to the oral environment during product use and periods of remineralization. The retainer was designed to house three partially demineralized bovine enamel samples. The study population was comprised of 30 adults, ages 18 to 70 years. The study consisted of two treatment phases with a washout period lasting seven ((+-) three) days preceding each treatment phase. A silica-based dentifrice without fluoride was used during the washout period. The Test Dentifrice used in this study contained 8% arginine, calcium carbonate, and 1450 ppm fluoride as sodium monofluorophosphate (MFP). The Control Dentifrice was silica-based and contained 1450 ppm fluoride as MFP. The treatment period consisted of a three-day lead-in period with the assigned product. The panelists brushed two times per day during the three-day lead-in period with the assigned product. On the fourth day, the panelists began brushing with the assigned product with the retainer in their mouth. The panelists brushed for one minute, followed by a one-minute swish with the slurry and a rinse with 15 ml of water in the morning, in the afternoon, and night with the retainer in the mouth. The panelists brushed only their teeth and not the specimens directly. Changes in mineral content before and after treatment were measured using a Knoop microhardness tester. Results: The results of the study showed that percent remineralization values for the Test Dentifrice and Control Dentifrice were 14.99% and 8.66%, respectively. A statistical analysis showed that the Test Dentifrice was statistically significantly more effective at remineralizing acid-softened enamel in comparison to the Control Dentifrice (p < 0.05). Conclusion: This study demonstrated that the Test Dentifrice with 8% arginine. calcium carbonate, and 1450 ppm lluoride as MFP is highly effective treatment for promoting remineralization of enamel that has been softened by an erosive challenge.
机译：目的：进行口腔内再矿化研究，以比较含有8％精氨酸和碳酸钙（Pro-Argin？Technology）和1450 ppm氟化物（单氟磷酸钠）的洁牙剂对酸软化牛牙釉质样品再矿化的能力。与氟化物为1450 ppm的二氧化硅基洁牙剂相比。方法：口腔内临床研究采用双盲，两次治疗，交叉设计，并在产品使用和再矿化期间使用上pa固定器将牙釉质标​​本暴露于口腔环境。固定器设计用于容纳三个部分脱盐的牛牙釉质样品。研究人群包括30位年龄在18至70岁之间的成年人。该研究包括两个治疗阶段，每个治疗阶段之前的洗脱期持续七（（+-）三）天。在冲洗期间使用不含氟化物的二氧化硅基洁牙剂。本研究中使用的测试牙粉含有8％的精氨酸，碳酸钙和1450 ppm的氟化物，为单氟磷酸钠（MFP）。对照牙粉是二氧化硅基的，并包含1450 ppm的氟化物作为MFP。治疗期包括为期三天的导入期和指定的产品。在为期三天的试用期内，小组成员每天使用分配的产品刷两次。在第四天，与会人员开始用口中的固定器刷洗指定的产品。小组成员刷一分钟，然后用淤浆刷洗一分钟，并在早晨，下午和晚上用保持器在嘴里用15 ml水冲洗。专门小组成员仅刷牙而不直接刷样品。使用努氏显微硬度测试仪测量处理前后矿物质含量的变化。结果：研究结果表明，测试牙粉和对照牙粉的再矿化百分比分别为14.99％和8.66％。统计分析表明，与对照牙粉相比，测试牙粉在矿化酸软化的牙釉质方面具有统计学上的显着提高（p <0.05）。结论：这项研究表明测试牙膏含8％的精氨酸。碳酸钙和1450 ppm的氯化铝（作为MFP）是一种有效的治疗方法，可促进珐琅质的再矿化，而牙釉质因侵蚀性侵蚀而软化。

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