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首页> 外文期刊>The journal of clinical hypertension. >Relationships of total adiponectin and molecular weight fractions of adiponectin with free testosterone in african men and premenopausal women.
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Relationships of total adiponectin and molecular weight fractions of adiponectin with free testosterone in african men and premenopausal women.

机译：非洲男性和绝经前女性中总脂联素和脂联素分子量分数与游离睾丸激素的关系。

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摘要

Adiponectin, a protein secreted by adipose tissue, has anti-inflammatory, antithrombogenic, and antidiabetogenic effects. Lower plasma adiponectin levels are present in diabetes, obesity, and the metabolic syndrome. Adiponectin levels are higher in women compared with men. The purpose of this study was to determine whether there is a relationship between total adiponectin, or the molecular weight fractions of adiponectin, and testosterone levels in African American men and premenopausal women. A sample (N=48) of men and premenopausal women was selected based on high and low serum-free testosterone level. All patients had data on blood pressure, metabolic risk factors, and sex hormone levels. Stored plasma samples were assayed for total adiponectin. Molecular weight fractions of adiponectin were separated by gel electrophoresis and quantified by Western blot. Data analysis compared adiponectin (total and fractions) levels with androgen status in both sexes. Among men with high testosterone levels, all fractions of adiponectin were significantly lower than those in men with low testosterone (P<.05). In women with high testosterone, total adiponectin (P=.02) and all fractions of molecular weight adiponectin (P<.05) were lower compared with those in women with low testosterone. Plasma adiponectin levels are lower in both men and premenopausal women with relatively higher testosterone levels.
机译：脂联素是脂肪组织分泌的一种蛋白质，具有抗炎，抗血栓形成和抗糖尿病的作用。糖尿病，肥胖症和代谢综合征中血浆脂联素水平较低。女性的脂联素水平高于男性。这项研究的目的是确定非洲裔美国人男性和绝经前女性的总脂联素或脂联素的分子量分数与睾丸激素水平之间是否存在关系。根据高和低无血清睾丸激素水平选择男性和绝经前女性的样本（N = 48）。所有患者都有血压，代谢危险因素和性激素水平的数据。分析储存的血浆样品中的总脂联素。脂联素的分子量级分通过凝胶电泳分离并通过蛋白质印迹法定量。数据分析比较了两性中脂联素（总和分数）水平与雄激素状态。在睾丸激素水平高的男性中，脂联素的所有分数均显着低于睾丸激素水平低的男性（P <.05）。与睾丸激素水平低的女性相比，睾丸激素水平高的女性的总脂联素（P = .02）和所有分子量脂联素（P <.05）要低。男性和绝经前女性的血浆脂联素水平较低，睾丸激素水平相对较高。

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