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首页> 外文期刊>The journal of clinical hypertension. >Associations among cardiometabolic risk factor clustering, weight status, and cardiovascular disease in an appalachian population.
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Associations among cardiometabolic risk factor clustering, weight status, and cardiovascular disease in an appalachian population.

机译：阿巴拉契亚人群中心脏代谢危险因素聚集，体重状况和心血管疾病之间的关联。

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It has been suggested that within the traditional body mass index (BMI) categories there is a heterogeneous pattern of cardiometabolic risk factor clustering. The objective of this research was to determine the associations among obesity, cardiometabolic abnormalities, and cardiovascular disease (CVD) in a large population-based study of Appalachian adults. The study comprised a cross-sectional survey of Appalachian adults residing in 6 communities in Ohio and West Virginia, who were aged 18 years and older (n=14,783, 50.9% women). The authors categorized BMI into normal weight (<25kg/m(2) ), overweight (25-29.9kg/m(2) ), and obese (>/=30kg/m(2) ). Cardiometabolic abnormalities were defined as the presence of hypertension, elevated triglycerides (>/=150mg/dL), decreased high-density lipoprotein cholesterol (<40mg/dL [men], <50mg/dL [women]), elevated fasting glucose (>/=100mg/dL)/diabetes, insulin resistance (homeostasis model assessment >5.13), or elevated C-reactive protein (>3mg/L). They found that 25.6% of normal-weight adults displayed clustering of >/=2 cardiometabolic abnormalities; in contrast, 36.8% of overweight/obese adults displayed no clustering. Compared with normal-weight persons without clustering of cardiometabolic abnormalities (referent), the odds ratio of CVD was 1.06 (95% confidence interval [CI], 0.84-1.34) among overweight/obese individuals without cardiometabolic clustering, 2.21 (95% CI, 1.74-2.81) among normal-weight individuals with cardiometabolic clustering, and 2.45 (95% CI, 2.02-2.97) among overweight/obese individuals with cardiometabolic clustering. These results suggest that within the traditional BMI categories, there may be heterogeneity of CVD risk depending on whether there is underlying clustering of cardiometabolic abnormalities.
机译：已经提出，在传统的体重指数（BMI）类别中，存在心脏代谢风险因素聚类的异质模式。这项研究的目的是在基于人群的阿巴拉契亚成年人的大型研究中确定肥胖，心脏代谢异常和心血管疾病（CVD）之间的关联。该研究包括一项横断面调查，调查对象是俄亥俄和西弗吉尼亚州6个社区的阿巴拉契亚成年人，他们的年龄均在18岁以上（n = 14,783，女性占50.9％）。作者将BMI分为正常体重（<25kg / m（2）），超重（25-29.9kg / m（2））和肥胖（> / = 30kg / m（2））。心脏代谢异常定义为高血压，甘油三酸酯升高（> / = 150mg / dL），高密度脂蛋白胆固醇降低（<40mg / dL [男性]，<50mg / dL [女性]），空腹血糖升高（> / = 100mg / dL）/糖尿病，胰岛素抵抗（体内稳态模型评估> 5.13）或C反应蛋白升高（> 3mg / L）。他们发现，有25.6％的体重正常的成年人表现出> / = 2的心脏代谢异常聚类。相比之下，超重/肥胖成年人中有36.8％的人没有聚类。与没有心脏代谢异常聚集的正常体重者（参考）相比，没有心脏代谢聚集的超重/肥胖个体的CVD比值比为1.06（95％置信区间[CI]，0.84-1.34），为2.21（95％CI，体重正常的具有心脏代谢聚集的个体为1.74-2.81），体重超重/肥胖的具有心脏代谢聚集的个体为2.45（95％CI，2.02-2.97）。这些结果表明，在传统的BMI类别中，CVD风险可能存在异质性，这取决于是否存在潜在的心脏代谢异常簇。

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