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首页> 外文期刊>The journal of clinical hypertension. >Relationship of hypertension, blood pressure, and blood pressure control with white matter abnormalities in the Women's Health Initiative Memory Study (WHIMS)-MRI trial.
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Relationship of hypertension, blood pressure, and blood pressure control with white matter abnormalities in the Women's Health Initiative Memory Study (WHIMS)-MRI trial.

机译：妇女健康倡议记忆研究（WHIMS）-MRI试验中，高血压，血压和血压控制与白质异常的关系。

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This paper evaluates the relationship of blood pressure (BP) levels at Women's Health Initiative (WHI) baseline, treatment of hypertension, and white matter abnormalities among women in conjugated equine estrogen (CEE) and medroxyprogesterone acetate and CEE-alone arms. The WHI Memory Study-Magnetic Resonance Imaging (WHIMS-MRI) trial scanned 1424 participants. BP levels at baseline were significantly positively related to abnormal white matter lesion (WML) volumes. Participants treated for hypertension but who had BP > or = 140/90 mm Hg had the greatest amount of WML volumes. Women with untreated BP > or = 140/90 mm Hg had intermediate WML volumes. Abnormal WML volumes were related to hypertension in most areas of the brain and were greater in the frontal lobe than in the occipital, parietal, or temporal lobes. Level of BP at baseline was strongly related to amount of WML volumes. The results of the study reinforce the relationship of hypertension and BP control and white matter abnormalities in the brain. The evidence to date supports tight control of BP levels, especially beginning at younger and middle age as a possible and perhaps only way to prevent dementia.
机译：本文评估了女性健康计划（WHI）基线血压，高血压治疗水平以及共轭马雌激素（CEE）和甲羟孕酮醋酸酯和仅使用CEE的女性的白质异常之间的关系。 WHI记忆研究-磁共振成像（WHIMS-MRI）试验扫描了1424名参与者。基线时的BP水平与异常白质病变（WML）量显着正相关。接受过高血压治疗但血压≥140/90 mm Hg的参与者的WML量最大。未经治疗的BP>或= 140/90 mm Hg的女性的WML量中等。 WML异常量与大脑大部分区域的高血压有关，并且额叶的额叶比枕叶，顶叶或颞叶的额叶更大。基线时的血压水平与WML量密切相关。研究结果加强了高血压和血压控制与脑白质异常之间的关系。迄今为止的证据支持对血压水平的严格控制，尤其是从年轻和中年开始，这可能是预防痴呆的一种可能且可能的唯一方法。

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