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首页> 外文期刊>The journal of clinical hypertension. >Are there pleiotropic effects of antihypertensive medications or is it all about the blood pressure in the patient with diabetes and hypertension?
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Are there pleiotropic effects of antihypertensive medications or is it all about the blood pressure in the patient with diabetes and hypertension?

机译：降压药物是否有多效药作用，还是与糖尿病和高血压患者的血压有关？

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摘要

Many small studies with varied surrogate end points and numerous preclinical data have suggested the likelihood of there being specific benefits that exceed simple blood pressure control with drug classes such as angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and calcium channel blockers, which may be particularly relevant to the patient with diabetes and hypertension. Large clinical trials, however, have provided only token support for this idea. Likewise, meta-analyses that have incorporated varied clinical trials, albeit with somewhat heterogeneous data, have not been particularly forthcoming in their support of this concept. In the patient with diabetes and hypertension, tight blood pressure control, more so than using a specific drug class, is the most important aspect of therapy.
机译：许多具有不同替代终点的小型研究和大量的临床前数据表明，用血管紧张素转化酶抑制剂，血管紧张素受体阻滞剂和钙通道阻滞剂等药物类别进行简单的血压控制可能会带来一些特定益处，而这些益处可能是与糖尿病和高血压患者特别相关。但是，大型临床试验仅为该想法提供了标记支持。同样，纳入了各种临床试验的荟萃分析尽管具有不同的数据，但在支持这一概念方面并不是特别有效。在糖尿病和高血压患者中，比使用特定的药物类别更严格地控​​制血压是治疗的最重要方面。

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