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Spironolactone revisited.

机译:螺内酯重访。

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摘要

We read with interest the study of Costa and colleagues regarding the effect of 25 mg/d to 50 mg/d spironolactone on blood pressure and serum metabolic parameters of obese individuals with the metabolic syndrome (MetS). More specifically, systolic and dia-stolic blood pressure, serum glucose and triglycerides significantly decreased, whereas high-density lipopro-tein cholesterol (HDL-C) increased 8 weeks following spironolactone treatment.In this regard, we have recently published preliminary results of a randomized clinical trial investigating the 8-week effect of 400 mg/d vitamin E (group 1) vs 25 mg/d spironolactone plus 400 mg/d vitamin E (group 2) [Correction after online publication 14-Jul-2011: units of vitamin e updated from IU/d to mg/d.] on serum metabolic parameters and insulin resistance (IR) in adults with histologically documented nonalcoholic fatty liver disease (NAFLD) (ClinicalTrials.gov NCT01147523).
机译:我们感兴趣地阅读了Costa和同事关于25 mg / d至50 mg / d螺内酯对肥胖和代谢综合征(MetS)个体血压和血清代谢参数的影响的研究。更具体地说,在螺内酯内酯治疗8周后,收缩压和diastolic血压,血清葡萄糖和甘油三酸酯显着降低,而高密度脂蛋白胆固醇(HDL-C)升高。一项随机临床试验,研究了400 mg / d维生素E(第1组)与25 mg / d螺内酯和400 mg / d维生素E(第2组)在8周内的作用[在线发表后的校正:2011年7月14日:单位为维生素E从IU / d更新为mg / d。]关于具有组织学证明的非酒精性脂肪性肝病(NAFLD)的成年人的血清代谢参数和胰岛素抵抗(IR)(ClinicalTrials.gov NCT01147523)。

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