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Relationship Between Body Mass Index and High Cystatin Levels Among US Adults

机译:体重指数与美国成年人胱抑素水平高的关系

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High cystatin C levels among patients without clinically recognized chronic kidney disease (CKD) may identify patients who are at preclinical stages of CKD. Higher body mass index (BMI) has been found to be associated with increased risk of CKD. However, the association between BMI and high cystatin C levels is not clear. The authors examined participants older than 20years from the National Health and Nutrition Examination Survey 1999 to 2002 (N=2583, 50.2% women). BMI was categorized as 25kg/m 2, 25-29.9kg/m 2, and ≥30kg/m 2. Main outcome was high cystatin C (1mg/dL) among patients without clinically recognized CKD (estimated glomerular filtration rate 60mL/min/1.73m 2 or microalbuminuria). Higher BMI was positively associated with high cystatin C, independent of age, sex, race-ethnicity, education, smoking, alcohol intake, cholesterol, and C-reactive protein levels. Compared with patients with BMI 25kg/m 2 (referent), the multivariable odds ratio (95% confidence interval) of high cystatin C was 2.53 (1.79-3.58) (P trend .0001 among patients with BMI ≥30kg/m 2). The association between BMI and high cystatin C persisted in subgroup analyses by sex, race-ethnicity, and among those without diabetes or hypertension. Among US adults without clinically recognized CKD, higher BMI levels were independently associated with high cystatin C levels.
机译:在没有临床公认的慢性肾脏病(CKD)的患者中,高的胱抑素C水平可以确定处于CKD临床前阶段的患者。已发现较高的体重指数(BMI)与CKD风险增加有关。但是,BMI与高半胱氨酸蛋白酶抑制剂C水平之间的关联尚不清楚。作者从1999年至2002年的美国国家健康和营养检查调查中检查了20岁以上的参与者(N = 2583,女性50.2%)。 BMI分为<25kg / m 2、25-29.9kg / m 2和≥30kg/ m2。主要结局是在没有临床认识的CKD(估计肾小球滤过率<60mL)的患者中,胱抑素C高(> 1mg / dL)。 /min/1.73m 2或微量白蛋白尿)。较高的BMI与半胱氨酸蛋白酶抑制剂C呈正相关,而与年龄,性别,种族,教育程度,吸烟,饮酒,胆固醇和C反应蛋白水平无关。与BMI <25kg / m 2的患者(参考)相比,高半胱氨酸蛋白酶抑制剂C的多变量比值比(95%置信区间)为2.53(1.79-3.58)(BMI≥30kg/ m 2的患者中P趋势<.0001 )。在按性别,种族,以及没有糖尿病或高血压的人群进行的亚组分析中,BMI与高半胱氨酸蛋白酶抑制剂C之间的关联仍然存在。在没有临床认识的CKD的美国成年人中,较高的BMI水平与高的胱抑素C水平独立相关。

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