Single-Pill Combination of Telmisartan/Amlodipine in Patients With Severe Hypertension: Results From the TEAMSTA Severe HTN Study

NeutelJ.M.; ManciaG.; BlackH.R.; Dahl?fB.; DefeoH.; LeyL.; ViniskoR.; DonovaT.; GotchevaN.; MilanovS.; MinchevaV.; PenchevaG.; ZlatarevaN.; RaevD.; StoimenovS.; PetranovS.; HornyI.; JerábekO.; KarenI.; KucharJ.C.; KrumlovLorencZ.; NagelJ.; PeterkaM.; ZídkováE.; BarucqF.; QueguinerA.; RobinF.; TouzetP.; BismuthM.; BourgoinM.; GiraldiC.; BretonN.; CombetR.; VenturiniG.; CausseP.; HenriotF.; KhennoufA.; LecaignardD.; CayronP.; ChalauxP.; ChaleonA.; ChalvignacA.; ForestierB.D.; DemeJ.-C.; FivelC.; DepoisierM.; DimonB.; FlosiM.; MacAgnoA.; RipollM.; GeronimiO.; MichalakB.; GeoffrayB.; HannoushE.; JacquetJ.-P.; JappyL.; JordanE.; LacoinF.; LefortD.; LemarieB.; MartocqG.; MichellierP.; NabedianE.; PercheronC.-A.; PerrinB.; PougetM.; RogerJ.-J.; RouviereG.; SacareauD.; TaminauD.; VuongM.-H.; ZimmermannD.; AndrásV.; LíviaT.; FerencP.; GabriellaN.; LászlóI.; IbolyaP.; JuditS.; KárolyZ.; JuditR.; BenedekI.; CristeaM.; Tatu-ChitoiuG.P.; DragulescuS.; GaitaD.; GeorgescuC.A.; MinescuB.; ManitiuI.; MateiA.; SalajanA.M.; AroutiounovG.; GordeevI.; IvlevaA.; MartynovA.; ZadionchenkoV.; FilippovA.; GoloshchekinB.

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Single-Pill Combination of Telmisartan/Amlodipine in Patients With Severe Hypertension: Results From the TEAMSTA Severe HTN Study

机译：严重高血压患者中替米沙坦/氨氯地平的单药联合使用：TEAMSTA严重HTN研究的结果

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This 8-week, randomized, double-blind, controlled study compared efficacy and tolerability of telmisartan/amlodipine (T/A) single-pill combination (SPC) vs the respective monotherapies in 858 patients with severe hypertension (systolic/diastolic blood pressure [SBP/DBP] ≥180/95 mmHg). At 8weeks, T/A provided significantly greater reductions from baseline in seated trough cuff SBP/DBP (-47.5mmHg/-18.7mmHg) vs T (P<.0001) or A (P=.0002) monotherapy; superior reductions were also evident at 1, 2, 4, and 6weeks. Blood pressure (BP) goal and response rates were consistently higher with T/A vs T or A. T/A was well tolerated, with less frequent treatment-related adverse events vs A (12.6% vs 16.4%) and a numerically lower incidence of peripheral edema and treatment discontinuation. In conclusion, treatment of patients with substantially elevated BP with T/A SPCs resulted in high and significantly greater BP reductions and higher BP goal and response rates than the respective monotherapies. T/A SPCs were well tolerated.

机译：这项为期8周的随机，双盲，对照研究比较了替米沙坦/氨氯地平（T / A）单药联合（SPC）与858例严重高血压（收缩压/舒张压[ SBP / DBP]≥180/ 95 mmHg）。在第8周时，相对于T（P <.0001）或A（P = .0002）单一疗法，坐位袖套SBP / DBP（-47.5mmHg / -18.7mmHg）的T / A与基线相比有显着更大的降低;在1、2、4和6周时也有明显的降低。 T / A相对于T或A的血压（BP）目标和应答率始终较高。T/ A耐受性良好，与治疗相关的不良事件相对于A较不常见（12.6％vs 16.4％），且发病率数值较低周围水肿和治疗中断。总之，与单独的单一疗法相比，使用T / A SPC治疗BP明显升高的患者可导致BP降低更高，显着更大，BP目标和应答率更高。 T / A SPC的耐受性良好。

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《The journal of clinical hypertension.》 |2012年第4期|共10页
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NeutelJ.M.; ManciaG.; BlackH.R.; Dahl?fB.; DefeoH.; LeyL.; ViniskoR.; DonovaT.; GotchevaN.; MilanovS.; MinchevaV.; PenchevaG.; ZlatarevaN.; RaevD.; StoimenovS.; PetranovS.; HornyI.; JerábekO.; KarenI.; KucharJ.C.; KrumlovLorencZ.; NagelJ.; PeterkaM.; ZídkováE.; BarucqF.; QueguinerA.; RobinF.; TouzetP.; BismuthM.; BourgoinM.; GiraldiC.; BretonN.; CombetR.; VenturiniG.; CausseP.; HenriotF.; KhennoufA.; LecaignardD.; CayronP.; ChalauxP.; ChaleonA.; ChalvignacA.; ForestierB.D.; DemeJ.-C.; FivelC.; DepoisierM.; DimonB.; FlosiM.; MacAgnoA.; RipollM.; GeronimiO.; MichalakB.; GeoffrayB.; HannoushE.; JacquetJ.-P.; JappyL.; JordanE.; LacoinF.; LefortD.; LemarieB.; MartocqG.; MichellierP.; NabedianE.; PercheronC.-A.; PerrinB.; PougetM.; RogerJ.-J.; RouviereG.; SacareauD.; TaminauD.; VuongM.-H.; ZimmermannD.; AndrásV.; LíviaT.; FerencP.; GabriellaN.; LászlóI.; IbolyaP.; JuditS.; KárolyZ.; JuditR.; BenedekI.; CristeaM.; Tatu-ChitoiuG.P.; DragulescuS.; GaitaD.; GeorgescuC.A.; MinescuB.; ManitiuI.; MateiA.; SalajanA.M.; AroutiounovG.; GordeevI.; IvlevaA.; MartynovA.; ZadionchenkoV.; FilippovA.; GoloshchekinB.;
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中图分类心脏、血管（循环系）疾病;
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1. Single-Pill Combination of Telmisartan/Amlodipine in Patients With Severe Hypertension: Results From the TEAMSTA Severe HTN Study [J] . NeutelJ.M., ManciaG., BlackH.R., The journal of clinical hypertension. . 2012,第4期

机译：严重高血压患者中替米沙坦/氨氯地平的单药联合使用：TEAMSTA严重HTN研究的结果
2. Switching patients with uncontrolled hypertension on amlodipine 10mg to single-pill combinations of telmisartan and amlodipine: Results of the TEAMSTA-10 study [J] . NeldamS., EdwardsC., JonesR. Current medical research and opinion . 2011,第11期

机译：将氨氯地平10mg不能控制的高血压患者切换为替米沙坦和氨氯地平单药组合：TEAMSTA-10研究的结果
3. Telmisartan and amlodipine single-pill combinations vs amlodipine monotherapy for superior blood pressure lowering and improved tolerability in patients with uncontrolled hypertension: results of the TEAMSTA-5 study. [J] . Neldam S, Lang M, Jones R The journal of clinical hypertension. . 2011,第7期

机译：替米沙坦和氨氯地平单药联用与氨氯地平单药联用可在血压不受控制的患者中出色地降低血压并改善耐受性：TEAMSTA-5研究的结果。
4. Dynamic non-linear changes in heart rate variability in patients with coronary heart disease and arterial hypertension treated by amlodipine besylate [C] . Krstacic, G., Krstacic, . 2003

机译：苯磺酸氨氯地平治疗冠心病和动脉高血压患者心率变异性的动态非线性变化
5. Mutation and epigenetic modulation of gene expression within plexiform lesions in patients with severe pulmonary hypertension. [D] . Yeager, Michael Eric. 2003

机译：严重肺动脉高压患者丛状病变内基因表达的突变和表观遗传调控。
6. Long-Term Tolerability and Efficacy of Single-Pill Combinations of Telmisartan 40–80 mg Plus Amlodipine 5 or 10 mg in Patients Whose Blood Pressure Was Not Initially Controlled by Amlodipine 5–10 mg: Open-Label Long-Term Follow-Ups of the TEAMSTA-5 and TEAMSTA-10 Studies [O] . Steen Neldam, Colin Edwards, Margreet Lang, 2012

机译：最初未获氨氯地平5-10 mg控制的患者的替米沙坦40-80 mg加氨氯地平5或10 mg单药组合的长期耐受性和功效：长期开放标签随访TEAMSTA-5和TEAMSTA-10研究
7. Single-pill Combination of Telmisartan 80mg/Amlodipine 10mg Provides Superior Blood Pressure Reductions in Patients with Severe Hypertension: Teamsta Severe HTN Study [O] . J. Neutel, G. Mancia, H. Black, 2011

机译：Telmisartan 80mg / amlodipine 10mg的单药组合提供了严重高血压患者的优异血压降低：Teamsta严重的HTN研究

Single-Pill Combination of Telmisartan/Amlodipine in Patients With Severe Hypertension: Results From the TEAMSTA Severe HTN Study

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