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首页> 外文期刊>The journal of clinical hypertension. >Catheter-Based Renal Sympathetic Denervation Improves Central Hemodynamics and Arterial Stiffness: A Pilot Study
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Catheter-Based Renal Sympathetic Denervation Improves Central Hemodynamics and Arterial Stiffness: A Pilot Study

机译：一项基于导管的肾脏交感神经去神经改善中央血流动力学和动脉僵硬度的初步研究

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摘要

Renal sympathetic denervation (RDN) is a novel treatment strategy for patients with resistant arterial hypertension. Recently, the Symplicity trials demonstrated significant peripheral blood pressure (BP) reduction. The present study aimed at measuring central aortic pressures and arterial stiffness as better predictors for cardiovascular risk in patients undergoing RDN. RDN was performed in 21 patients (systolic peripheral BP =150 mm Hg) with an Ardian/Medtronic (Mountain View, CA) ablation system. Data were recorded with an Arteriograph. After 6 months, peripheral systolic BP was reduced by 6.1% (P<.05) while central systolic pressure was reduced by 7.0% (P<.05). Subgroup analysis showed that in responders, peripheral systolic BP was reduced by 16.1% (P<.01) while central systolic pressure was reduced by 18.3% (P<.01). Arterial stiffness improved significantly. Aortic augmentation index (AIx) improved by 9.5% (P<.05). In responders, AIx improved by 19.2% (P<.02). Pulse wave velocity (PWV) was high at baseline (10.8 m/s) and improved by 10.4% (P<.05). In responders, PWV improved by 13.7% (P<.05). Multivariate analysis showed that short-term effects on PWV were BP-related, whereas during follow-up, improvement of PWV becomes BP-unrelated. RDN improves peripheral and central blood pressure as well as arterial stiffness and, thus, may improve cardiovascular outcome. J Clin Hypertens (Greenwich). 2012;14:861870. (c) 2012 Wiley Periodicals, Inc.
机译：肾交感神经去神经支配术（RDN）是一种抗高血压性高血压患者的新型治疗策略。最近，Symplicity试验显示出外周血压（BP）明显降低。本研究旨在测量中心主动脉压力和动脉僵硬度，作为接受RDN的患者心血管风险的更好预测指标。使用Ardian / Medtronic（Mountain View，CA）消融系统对21例患者（收缩末梢血压BP = 150 mm Hg）进行RDN。用动脉造影仪记录数据。 6个月后，外周收缩压降低6.1％（P <.05），而中央收缩压降低7.0％（P <.05）。亚组分析显示，在反应者中，外周收缩压降低了16.1％（P <.01），而中央收缩压降低了18.3％（P <.01）。动脉僵硬度明显改善。主动脉扩张指数（AIx）改善了9.5％（P <.05）。在应答者中，AIx改善了19.2％（P <.02）。脉搏波速度（PWV）在基线时很高（10.8 m / s），提高了10.4％（P <.05）。在应答者中，PWV提高了13.7％（P <.05）。多变量分析表明，短期内对PWV的影响与血压有关，而在随访期间，对PWV的改善与血压无关。 RDN可改善周围和中央血压以及动脉僵硬度，因此可以改善心血管疾病的预后。 J临床高血压（格林威治）。 2012; 14：861870。 （c）2012年威利期刊有限公司

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