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首页> 外文期刊>The journal of clinical hypertension. >Hypertension in pregnancy is a risk factor for microalbuminuria later in life
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Hypertension in pregnancy is a risk factor for microalbuminuria later in life

机译：妊娠高血压是生命后期微量白蛋白尿的危险因素

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The authors aimed to compare renal function by estimated glomerular filtration rate and albuminuria in 3 groups of women: nulliparous women, women with a history of normotensive pregnancies, and women with a history of at least one hypertensive pregnancy. Women who participated in the second Family Blood Pressure Program Study visit (2000-2004) and had serum creatinine and urine albumin measurements (n=3015) were categorized as having had no pregnancy lasting >6 months (n=341), having had only normotensive pregnancies (n=2199), or having had at least 1 pregnancy with hypertension (n=475) based on a standardized questionnaire. Women who reported having had at least one pregnancy with hypertension were significantly more likely to be hypertensive (75.6% vs 59.4%, P < .001), diabetic (34.2% vs 27.3%, P ≤ .001), and have higher body mass index (32.8 vs 30.5, P < .001) than those who reported normotensive pregnancies. There was a significantly greater risk of microalbuminuria (urine albumin-creatinine ratio >25 mg/g) in those who reported at least one pregnancy with hypertension (odds ratio, 1.37; confidence interval, 1.02-1.85; P=04) than in those with normotensive pregnancies, after adjusting for risk factors for chronic kidney and cardiovascular disease. Hypertension in pregnancy is associated with an increased risk of future microalbuminuria.
机译：作者的目的是通过估计的肾小球滤过率和白蛋白尿在3组妇女中比较肾功能：未生育妇女，有血压正常妊娠史的妇女和有至少一次高血压妊娠病史的妇女。参加第二次家庭血压计划研究访问（2000-2004年）并进行了血清肌酐和尿白蛋白测定（n = 3015）的妇女被归类为怀孕持续时间不超过6个月（n = 341）的妇女。正常妊娠（n = 2199），或至少有1次妊娠合并高血压（n = 475）（基于标准化问卷）。报告至少怀孕过一次高血压的女性更有可能出现高血压（75.6％vs 59.4％，P <.001），糖尿病（34.2％vs 27.3％，P≤.001）和更高的体重指数（32.8 vs 30.5，P <.001）高于那些血压正常的孕妇。与那些至少有一次妊娠合并高血压的人相比，尿白蛋白尿（尿白蛋白-肌酐比> 25 mg / g）的风险显着更高（几率1.37;置信区间1.02-1.85; P = 04）。在调整了慢性肾脏和心血管疾病的危险因素后，进行了正常妊娠的妊娠。妊娠高血压与未来微量白蛋白尿的风险增加有关。

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