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首页> 外文期刊>The journal of clinical hypertension. >Risk of Methylphenidate-Induced Prehypertension in Normotensive Adult Smokers With Attention Deficit Hyperactivity Disorder
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Risk of Methylphenidate-Induced Prehypertension in Normotensive Adult Smokers With Attention Deficit Hyperactivity Disorder

机译：血压正常的成年吸烟者患有注意力不足过动症的哌醋甲酯诱发高血压的风险

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摘要

The authors studied predictors of methylphenidate-induced increases in blood pressure (BP). In this secondary analysis of a randomized, double-blind, placebo-controlled smoking cessation trial, nonhypertensive adult smokers with attention deficit hyperactivity disorder randomized to osmotic-release oral system methylphenidate (OROS-MPH) (n=115) were matched one-to-one on baseline systolic BP (SBP) (±5mmHg) with participants randomized to placebo (n=115) and followed for 10weeks. In adjusted mixed linear models of SBP and diastolic BP (DBP), baseline normal SBP (P<.0001) and DBP (P<.0001) were associated with significant OROS-MPH-induced increases compared with placebo, whereas significant increases were not observed in participants with baseline prehypertensive SBP (P=27) and DBP (P=79). Participants randomized to OROS-MPH with baseline normal BP had increased odds of developing either systolic (odds ratio [OR], 3.32; 95% confidence interval [CI], 1.41-8.37; P=006) or diastolic prehypertension (OR, 4.32; 95% CI, 1.56-14.0; P=004) compared with placebo using simple logistic regression. The authors demonstrated an augmented OROS-MPH-induced BP elevation and risk of prehypertension in adults with baseline normal BP. Significantly increased BP was not observed in adults with baseline prehypertension.
机译：作者研究了哌醋甲酯诱导的血压升高的预测因素。在这项随机，双盲，安慰剂对照戒烟试验的次要分析中，将患有注意力缺陷多动障碍的非高血压成年吸烟者随机分配到渗透释放口服系统哌醋甲酯（OROS-MPH）（n = 115）中-基线收缩压（SBP）（±5mmHg）一项，参与者随机分配至安慰剂组（n = 115），并随访10周。在调整过的SBP和舒张压BP（DBP）的混合线性模型中，基线正常SBP（P <.0001）和DBP（P <.0001）与OROS-MPH引起的安慰剂显着增加相关，而显着增加与安慰剂无关。在基线高血压前期SBP（P = 27）和DBP（P = 79）的参与者中观察到。随机分配至基线血压正常的OROS-MPH的参与者发生收缩压（优势比[OR]，3.32; 95％置信区间[CI]，1.41-8.37; P = 006）或舒张前高血压（OR，4.32; 95％置信区间，CI）的可能性增加。 95％CI（1.56-14.0; P = 004），而安慰剂则使用简单的逻辑回归分析。作者证明，在基线血压正常的成年人中，由OROS-MPH引起的BP升高和高血压前期风险增加。在基线高血压前期的成年人中未观察到明显的血压升高。

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