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High-sensitivity cardiac troponin t predicts nondipper hypertension in newly diagnosed hypertensive patients

机译:高敏感性心肌肌钙蛋白t可预测新诊断的高血压患者的非d型高血压

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摘要

The increased prognostic accuracy of the high-sensitivity cardiac troponin T (hs-cTnT) assay vs the conventional cTnT assay has recently been reported in hypertensive patients. The authors aimed to investigate the significance of serum hs-cTnT marker for prediction of nondipper hypertension (HTN) in hypertensive patients. A total of 317 patients with newly diagnosed HTN were studied. The patients were divided into two groups: 198 dipper hypertensive patients (mean age, 51.7±5.1 years) and 119 nondipper hypertensive patients (mean age, 53.4±7.6 years). Hs-cTnT and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured in all patients. hs-cTnT and NT-proBNP were independent predictors for nondipper HTN (P < .05 for all). The cutoff value of hs-cTnT obtained by the receiver operator curve analysis was 7.55 ng/L for the prediction of nondipper HTN (sensitivity: 79%, specificity: 70%; 95% confidence interval, 0.769-0.860; P < .001). In patients with HTN, higher serum concentration of hs-cTnT even within normal range is an independent predictor of nondipper HTN.
机译:最近有报道称,高血压患者中高敏感性心脏肌钙蛋白T(hs-cTnT)测定法与常规cTnT测定法相比预后准确性更高。作者旨在研究血清hs-cTnT标记对于预测高血压患者的非d型高血压(HTN)的意义。共研究了317例新诊断的HTN患者。将患者分为两组:198例北斗星高血压患者(平均年龄,51.7±5.1岁)和119例非d斗性高血压患者(平均年龄,53.4±7.6岁)。在所有患者中均测量了Hs-cTnT和N端脑钠肽(NT-proBNP)。 hs-cTnT和NT-proBNP是非北斗七星HTN的独立预测因子(所有P均<0.05)。通过接收者操作员曲线分析获得的hs-cTnT的临界值为7.55 ng / L,用于预测非北斗星HTN(敏感性:79%,特异性:70%; 95%置信区间,0.769-0.860; P <.001) 。在HTN患者中,即使在正常范围内,较高的hs-cTnT血清浓度也是非斗型HTN的独立预测指标。

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