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首页> 外文期刊>The journal of clinical hypertension. >Assessment of endothelial function by means of flow-mediated changes using pulse wave velocity.
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Assessment of endothelial function by means of flow-mediated changes using pulse wave velocity.

机译：使用脉搏波速度通过血流介导的变化评估内皮功能。

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Endothelial dysfunction is a leading cause of early development of cardiovascular diseases. Endothelial function can be assessed using ultrasound methods to watch the arterial flow-mediated dilation. It is also possible to find changes in pulse wave velocity (PWV) after induced ischemia related to the vessel diameter changes. Pre- and post-induced ischemia carotid-radial PWV was recorded in 226 hypertensive patients (150 women [63.5+/-12.4 years old] and 76 men [63.2+/-11.8 years old] and 55 healthy patients (38 women [63.1+/-12.6 years old] and 17 men [54.8+/-12.8 years old]). The authors considered normal endothelial function a PWV reduction of 5% from baseline. To assess nondependent endothelial dilation the authors performed carotid-radial PWV after sublingual administration of 5 mg of isosorbide dinitrate in a group of patients with abnormal flow-mediated dilation. A significant PWV reduction of 9.8% in normal patients and only 1.2% among hypertensive patients (P<.0005) was found. After sublingual isosorbide dinitrate intake the authors observed a greater fall in PWV (14%) than that observed in healthy people after induced ischemia. Carotid-radial PWV after induced ischemia decreased significantly in normal participants. No significant changes were observed in hypertensive patients. These results may offer a reliable tool to assess endothelial function in medium-size arteries.
机译：内皮功能障碍是心血管疾病早期发展的主要原因。可以使用超声方法评估内皮功能，以观察动脉血流介导的扩张。在诱发的与血管直径变化相关的局部缺血后，还可能发现脉搏波速度（PWV）的变化。在226名高血压患者（150名女性[63.5 +/- 12.4岁]和76名男性[63.2 +/- 11.8岁]）和55名健康患者（38名女性[63.1]）中记录了诱导前和后缺血性颈动脉-动脉PWV +/- 12.6岁]和17位男性[54.8 +/- 12.8岁]）。作者认为正常的内皮功能较基线降低了5％;为评估非依赖性内皮扩张，作者在舌下后进行了颈动脉car动脉PWV在一组流量异常介导的扩张患者中使用5mg硝酸异山梨酯，正常患者的PWV显着降低9.8％，而在高血压患者中仅降低1.2％（P <.0005）。作者观察到健康人诱发缺血后的PWV下降幅度较大（14％），正常受试者诱发缺血后颈动脉-动脉PWV显着下降，高血压患者未见明显变化。评估中型动脉内皮功能的可靠工具。

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