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首页> 外文期刊>The journal of clinical hypertension. >Low medication adherence and the incidence of stroke symptoms among individuals with hypertension: the REGARDS study.
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Low medication adherence and the incidence of stroke symptoms among individuals with hypertension: the REGARDS study.

机译：高血压患者中药物依从性低和中风症状的发生率：REGARDS研究。

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The authors analyzed data on 9950 participants taking antihypertensive medications in the nationwide Reasons for Geographic and Racial Differences in Stroke (REGARDS) study to determine the association between medication adherence and incident stroke symptoms. Medication adherence was assessed using a validated 4-item self-report scale and participants were categorized into 4 groups (scores of 0, 1, 2, and 3 or 4, with higher scores indicating worse adherence). The incidence of 6 stroke symptoms (sudden weakness on one side of the body, numbness, painless loss of vision in one or both eyes, loss of half vision, losing the ability to understand people, and losing the ability to express oneself verbally or in writing) was assessed via telephone interviews every 6 months. During a median of 4 years, the incidence of any stroke symptom was 14.6%, 17.9%, 20.2%, and 24.9% among participants with adherence scores of 0, 1, 2, and 3 or 4, respectively (P<.001). The multivariable adjusted hazard ratio (95% confidence interval) for any stroke symptom associated with adherence scores of 1, 2, and 3 or 4, vs 0, was 1.20 (1.04-1.39), 1.23 (0.94-1.60), and 1.59 (1.08-2.33), respectively (P<.001). Worse adherence was also associated with higher multivariable adjusted hazard ratios for each of the 6 stroke symptoms.
机译：作者分析了在全国范围内“中风的地理和种族差异原因”（REGARDS）研究中9950名服用降压药的参与者的数据，以确定药物依从性与中风症状之间的关联。使用经过验证的4项自我报告量表评估药物依从性，并将参与者分为4组（得分分别为0、1、2和3或4，得分越高表明依从性越差）。 6种中风症状的发生率（身体一侧突然虚弱，麻木，一只或两只眼睛的无痛视力丧失，半视力丧失，失去了解人的能力以及丧失口头表达能力或口头表达能力）每6个月通过电话采访进行评估）。在4年中位数中，依从性得分分别为0、1、2、3或4的参与者中任何中风症状的发生率分别为14.6％，17.9％，20.2％和24.9％（P <.001） 。与1、2、3或4、0的依从性得分相关的任何中风症状的多变量调整风险比（95％置信区间）为1.20（1.04-1.39），1.23（0.94-1.60）和1.59（ 1.08-2.33）（P <.001）。对于6种中风症状中的每一种，依从性差还与较高的多变量调整的危险比相关。

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