CONDENSED ISOQUINOLINES 31. REACTION OF 5-ARYL-3-HALO-12H-ISOQUINO[2,3-a]QUINAZOLINES WITH ELECTROPHILIC REAGENTS

Potikha LM; Kisil VM; Turov AV; Kovtunenko VA

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CONDENSED ISOQUINOLINES 31. REACTION OF 5-ARYL-3-HALO-12H-ISOQUINO[2,3-a]QUINAZOLINES WITH ELECTROPHILIC REAGENTS

机译：稠合异喹啉31. 5-ARYL-3-HALO-12H-异喹啉[2,3-a]喹唑啉与亲电试剂的反应

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Treatment of 5-aryl-3-halo-12H-isoquino[2,3-a]quinazolines with electrophilic reagents readily forms their oxidation products. Acylation of the 3-chloro-5-phenyl-7,12-dihydroisoquino[2,3-a]quinazolinium perchlorate with Ac2O in the presence of pyridine gave the product of electrophilic substitution at the C-7 atom 1-(3-chloro-5-phenyl-12H-isoquino[2,3-a]quinazolin-7-yl)-1-ethanone. By the same route phenacyl bromides react with the anhydro base 1 to give 5-aryl-7-(2-aryl-2-oxoethyl)-3-halo-isoquino[2,3-a]quinazolin-13-ium bromides. These salts readily react with nucleophilic reagents to form the products of addition at the C-12 atom.

机译：用亲电子试剂处理5-芳基-3-卤代-12H-异喹啉[2,3-a]喹唑啉容易形成其氧化产物。在吡啶存在下，将3-氯-5-苯基-7,12-二氢异喹啉[2,3-a]喹唑啉鎓与Ac2O酰化，得到C-7原子1-（3-氯）的亲电子取代产物-5-苯基-12H-异喹[2,3-a]喹唑啉-7-基）-1-乙酮。通过相同的途径，苯甲酰基溴化物与脱水碱1反应，得到5-芳基-7-（2-芳基-2-氧代乙基）-3-卤代-异喹啉[2，3-a]喹唑啉-13-溴化物。这些盐容易与亲核试剂反应形成C-12原子上的加成产物。

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来源
《Chemistry of heterocyclic compounds》 |2008年第7期|共7页
作者
Potikha LM; Kisil VM; Turov AV; Kovtunenko VA;
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正文语种 eng
中图分类杂环化合物;
关键词
5-aryl-12H-isoquino2; 3-aquinazoline; 5-arylisoquino2; 3-aquinazolin-13-ium bromides; acylation; borohydride reduction; oxidation; ENAMINES;

机译：5-芳基-12H-异喹[2;3-a]喹唑啉;5-芳基异喹[2;3-a]喹唑啉-13-溴化物;酰化;硼氢化物还原;氧化;烯胺;

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1. CONDENSED ISOQUINOLINES 31. REACTION OF 5-ARYL-3-HALO-12H-ISOQUINO[2,3-a]QUINAZOLINES WITH ELECTROPHILIC REAGENTS [J] . Potikha LM, Kisil VM, Turov AV, Chemistry of heterocyclic compounds . 2008,第7期

机译：稠合异喹啉31. 5-ARYL-3-HALO-12H-异喹啉[2,3-a]喹唑啉与亲电试剂的反应
2. Condensed isoquinolines 29. Oxidation reactions of 5-aryl-7,12-dihydroisoquino[2,3-a]quinazolinium salts [J] . Potikha LM, Kisil VM, Turov AV, Chemistry of heterocyclic compounds . 2008,第3期

机译：缩合异喹啉29. 5-芳基-7,12-二氢异喹[2,3-a]喹唑啉盐的氧化反应
3. Reactions of Quinazoline Alkaloids and their Derivatives with Electrophilic Reagents [J] . Samarov ZU, Khakimova ZM, Okmanov R, Chemistry of Natural Compounds . 2008,第4期

机译：喹唑啉生物碱及其衍生物与亲电试剂的反应
4. Electrophilic Hydroxylation and Electrophilic Amination of Electronrich Substrates: Reagents, Mechanism, and Synthetic Applications [C] . Silvio Quici Seminars in organic synthesis : XXII summer school "A. Corbella" . 1997

机译：电子富集底物的亲电子羟基化和亲电子胺化：试剂，机理和合成应用
5. QUINO(1,2-C)QUINAZOLINES AND INDAZOLO(2,3-A)QUINOLINES: ANALOGS OF THE ANTITUMOR BENZO(C)PHENANTHRIDINE ALKALOIDS NITIDINE AND FAGARONINE. [D] . PHILLIPS, STEVEN DELBERT. 1981

机译：喹诺（1,2-C）喹啉和吲哚并（2,3-A）喹啉：苯并（C）菲啶胺碱，亚硝胺和法加罗宁的类似物。
6. New methodology for the preparation of 3-hydroxy-2-pyridinone (32-HOPO) chelators and extractants. Part 2. Reactions of alcohols phenols and thiols with an electrophilic 32-HOPO reagent [O] . Sumathi Chittamuru, Timothy N. Lambert, Gloria Martinez, -1

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7. Regioselectivity of Electrophilic Attack on 4-Methyl-1-thioxo-1,2,4,5-tetrahydro[1,2,4]triazolo[4,3-a]quinazolin-5-one. Part 1: Reactions at the Sulfur Atom [O] . Pavel Pazdera, Michal Ã„ÂŒajan, Walid Fathalla 2001

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8. Electrophilic Displacement Reactions Involving Organoboron Compounds Two Novel Reactions Involving Areneboronic Aoids and Halogens [R] . A. D. Price, L. E. Benjamin 1956

机译：涉及有机硼化合物的亲电位移反应涉及芳烃类和类卤素的两种新反应

CONDENSED ISOQUINOLINES 31. REACTION OF 5-ARYL-3-HALO-12H-ISOQUINO[2,3-a]QUINAZOLINES WITH ELECTROPHILIC REAGENTS

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