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首页> 外文期刊>Protoplasma: An International Journal of Cell Biology >Dynamics and cross talk of junctional proteins: a molecular basis for the regulation of cell adhesion and epithelial polarity
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Dynamics and cross talk of junctional proteins: a molecular basis for the regulation of cell adhesion and epithelial polarity

机译：连接蛋白的动力学和串扰：调节细胞粘附和上皮极性的分子基础

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摘要

Junctional complexes, including tight junctions, actin-associated adherens junctions, and intermediate-filament-associated desmosomes, are major structural components in epithelial cells that are essential for the establishment of epithelial cell polarity. Various signaling molecules, involving tyrosine kinases and phosphatases, small GTPases, and components of the Wnt signaling pathway regulate the assembly and disassembly of junctional complexes during embryonic development and cell differentiation. The levels of regulation involve the coordinated interactions of junctional proteins with the cytoskeleton, the interplay between different junctional complexes, and the active participation of junctional proteins in signaling cascades. The interaction of beta-catenin with both components of adherens junctions and proteins of the Wnt/wingless signaling pathway is the best characterized mechanism to date that links cell adhesion to gene expression and cell fate determination. [References: 73]
机译：交界复合体，包括紧密连接，肌动蛋白相关的粘附连接和中间丝相关的桥粒，是上皮细胞中的主要结构成分，对于建立上皮细胞极性至关重要。涉及酪氨酸激酶和磷酸酶，小的GTP酶以及Wnt信号通路成分的各种信号分子在胚胎发育和细胞分化过程中调节连接复合物的组装和拆卸。调节水平涉及连接蛋白与细胞骨架的协同相互作用，不同连接复合物之间的相互作用以及连接蛋白在信号级联反应中的主动参与。 β-catenin与粘附连接和Wnt / winging信号通路蛋白的相互作用是迄今为止将细胞粘附与基因表达和细胞命运确定联系起来的最有特色的机制。 [参考：73]

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