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首页> 外文期刊>Protoplasma: An International Journal of Cell Biology >Comparison between the effects of fusicoccin, Tunicamycin, and Brefeldin A on programmed cell death of cultured sycamore (Acer pseudoplatanus L.) cells
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Comparison between the effects of fusicoccin, Tunicamycin, and Brefeldin A on programmed cell death of cultured sycamore (Acer pseudoplatanus L.) cells

机译：富西考星，衣霉素和布雷菲德菌素A对美国梧桐（Acer pseudoplatanus L.）细胞程序性细胞死亡的影响之间的比较

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摘要

Programmed cell death occurs in plants during several developmental processes and during the expression of resistance to pathogen attack (i.e., the hypersensitive response). An unsolved question of plant programmed cell death is whether a unique signaling pathway or different, possibly convergent pathways exist. This problem was addressed in cultured sycamore (Acer pseudoplatanus L.) cells by comparing the effects of fusicoccin, Tunicamycin and Brefeldin A, inducers of programmed cell death with well-defined molecular and cellular targets, on some of the parameters involved in the regulation of this process. In addition to cell death, the inducers are able to stimulate the production of H2O2, the leakage of cytochrome c from mitochondria, the accumulation of cytosolic 14-3-3 proteins, and changes at the endoplasmic reticulum level, such as accumulation of the molecular chaperone binding protein and modifications in the organelle architecture. Interestingly, no additive effect on any of these parameters is observed when fusicoccin is administered in combination with Tunicamycin or Brefeldin A. Thus, these inducers seem to utilize the same or largely coincident pathways to induce programmed cell death and involvement of the endoplasmic reticulum, in addition to that of mitochondria, appears to be a common step.
机译：程序性细胞死亡在植物的几个发育过程中以及对病原体攻击的抗性表达（即超敏反应）中发生。植物程序性细胞死亡的一个尚未解决的问题是是否存在独特的信号传导途径或不同的，可能会聚的途径。在培养的无花果（Acer pseudoplatanus L.）细胞中，该问题的解决方法是通过比较氟尿嘧啶，突尼霉素和布雷菲德菌素A（编程性细胞死亡诱导剂与明确定义的分子和细胞靶标）对调节细胞凋亡的某些参数的影响这个流程。除细胞死亡外，诱导物还能够刺激H2O2的产生，线粒体中细胞色素c的泄漏，胞质14-3-3蛋白的积累以及内质网水平的变化，例如分子的积累。伴侣结合蛋白和细胞器结构的修饰。有趣的是，当将fusicoccin与Tunicamycin或Brefeldin A组合使用时，未观察到对任何这些参数的累加效应。因此，这些诱导剂似乎利用相同或基本一致的途径诱导程序性细胞死亡和内质网参与。除了线粒体，这似乎是一个常见步骤。

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