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首页> 外文期刊>Protoplasma: An International Journal of Cell Biology >Nonmuscle caldesmon: its distribution and involvement in various cellular processes
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Nonmuscle caldesmon: its distribution and involvement in various cellular processes

机译：非肌肉Caldesmon：其在各种细胞过程中的分布和参与

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摘要

Smooth muscle caldesmon is a thin-filament constituent which takes part in the Ca2+-dependent regulation of actomyosin motor activity which converts chemical energy of ATP into force. The molecular anatomy of its counterpart found in a variety of nonmuscle cells is similar. Both contain about 20 nm long terminal domains responsible for functionally important multisite interactions with filamentous actin, tropomyosin, Ca2+/calmodulin, and myosin and differ by a 35 nm long central, alpha-helical fragment which is lacking in nonmuscle caldesmon. The different structural organisation of nonmuscle cells and thus distinct distribution of caldesmon implicates its different physiological functions. Due to direct interaction with globular and filamentous actin as well as with tropomyosin, nonmuscle caldesmon is involved in the assembly, dynamics, or stability of microfilaments, whereas the indirect inhibitory effect on interaction of the microfilaments with myosin causes its participation in the regulation of cell contraction and intracellular motional processes. These functions of nonmuscle caldesmon of vertebrates are controlled by Ca2+/calmodulin (or other Ca2+-binding proteins) or caldesmon phosphorylation catalysed by various protein kinases. Examples of nonmuscle caldesmon involvement. in functions of higher and lower eukaryote, animal and plant cells are presented.
机译：平滑肌卡尔德斯蒙是一种细丝成分，参与了对肌动球蛋白运动活性的Ca2 +依赖性调节，从而将ATP的化学能转化为力。在多种非肌肉细胞中发现的对应物的分子解剖结构相似。两者都包含约20 nm长的末端结构域，负责与丝状肌动蛋白，原肌球蛋白，Ca2 + /钙调蛋白和肌球蛋白的功能上重要的多位相互作用，并且相差35 nm长的中央α-螺旋片段，这是非肌肉卡尔德蒙所缺乏的。非肌肉细胞的不同结构组织以及由此导致的卡尔德斯蒙的不同分布暗示了其不同的生理功能。由于与球状和丝状肌动蛋白以及原肌球蛋白的直接相互作用，非肌钙蛋白参与了微丝的组装，动力学或稳定性，而对微丝与肌球蛋白相互作用的间接抑制作用导致其参与细胞的调节。收缩和细胞内运动过程。脊椎动物非肌肉Caldesmon的这些功能受Ca2 + /钙调蛋白（或其他Ca2 +结合蛋白）控制，或受多种蛋白激酶催化的Caldesmon磷酸化作用控制。非肌肉Caldesmon参与的示例。在高等和低等真核生物的功能中，提出了动植物细胞。

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