The V-ATPase inhibitors concanamycin A and bafilomycin A lead to Golgi swelling in tobacco BY-2 cells

Robinson DG; Albrecht S; Moriysu Y

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The V-ATPase inhibitors concanamycin A and bafilomycin A lead to Golgi swelling in tobacco BY-2 cells

机译：V-ATPase抑制剂伴刀豆球蛋白A和杆状霉素A导致烟草BY-2细胞中的高尔基体肿胀

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Concanamycin A and bafilomycin A are well-known inhibitors of V-ATPase activity. It is known that they interfere with intracellular protein trafficking in both animal and plant cells, but a cellular target for their action in plant cells has not been defined. Here we show that treatment with these inhibitors leads to a massive vacuolation of the Golgi apparatus. The effect is similar, but not identical, to that previously described for the Na+/K+ ionophores and is reversible after washing.

机译：伴刀霉素A和巴氟霉素A是众所周知的V-ATP酶活性的抑制剂。已知它们干扰动物和植物细胞中的细胞内蛋白运输，但是尚未定义其在植物细胞中作用的细胞靶标。在这里，我们表明使用这些抑制剂进行治疗会导致高尔基体大量空泡化。效果与先前描述的Na + / K +离子载体相似但不完全相同，清洗后可逆。

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《Protoplasma: An International Journal of Cell Biology》 |2004年第4期|共6页
作者
Robinson DG; Albrecht S; Moriysu Y;
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正文语种 eng
中图分类细胞形态学;
关键词
bafilomycin A; concanamycin A; tobacco BY-2 cells; Golgi apparatus; vacuolation; SUSPENSION-CULTURED CELLS; PLANT-CELLS; ADENOSINE-TRIPHOSPHATASES; SECRETORY PATHWAY; VACUOLAR; GLYCOSYLATION; APPARATUS; PROTEIN; ORGANELLE; ENZYMES;

机译：巴非霉素A;伴刀霉素A;烟草BY-2细胞;高尔基体;真空;悬浮培养细胞;植物细胞;腺苷三磷酸酶;分泌途径;液泡;糖基化;装置;蛋白质;器官;

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专利

1. The V-ATPase inhibitors concanamycin A and bafilomycin A lead to Golgi swelling in tobacco BY-2 cells [J] . D. G. Robinson, S. Albrecht, Y. Moriysu Protoplasma . 2004,第3a4期

机译：V-ATPase抑制剂伴刀豆球蛋白A和杆状霉素A导致烟草BY-2细胞中的高尔基体肿胀
2. The V-ATPase inhibitors concanamycin A and bafilomycin A lead to Golgi swelling in tobacco BY-2 cells [J] . Robinson DG, Albrecht S, Moriysu Y Protoplasma: An International Journal of Cell Biology . 2004,第3a4期

机译：V-ATPase抑制剂伴刀豆球蛋白A和杆状霉素A导致烟草BY-2细胞中的高尔基体肿胀
3. Folimycin (Concanamycin A), a Specific Inhibitor of V-ATPase, Blocks Intracellular Translocation of the Glycoprotein of Vesicular Stomatitis Virus before Arrival to the Golgi Apparatus [J] . Akira Takatsuki, Kenji Nagao, Makari Yamasaki, Cell structure and function . 1993,第3期

机译：Folimycin（Concanamycin A），一种V-ATPase的特异性抑制剂，可在到达高尔基体之前阻止水泡性口腔炎病毒糖蛋白的细胞内转运
4. Study on Toxicity of Copper Oxide Engineered Nanoparticles to Tobacco BY-2 Cells [C] . Lili Xu, Haijun Sui, Xiaoyun Liu, International Conference on Mechanical Science and Engineering . 2013

机译：铜氧化铜工程纳米粒子毒性研究烟草 - 2细胞的毒性
5. Auxin deprivation induces Golgi stack differentiation in suspension-cultured tobacco BY-2 cells [D] . Winicur, Zev Michael 1997

机译：生长素剥夺在悬浮培养的烟草BY-2细胞中诱导高尔基体堆栈分化
6. Dissection of autophagy in tobacco BY-2 cells under sucrose starvation conditions using the vacuolar H+-ATPase inhibitor concanamycin A and the autophagy-related protein Atg8 [O] . Kanako Yano, Takahiro Yanagisawa, Kyosuke Mukae, 2015

机译：使用液泡H + -ATPase抑制剂伴刀豆球蛋白A和自噬相关蛋白Atg8在蔗糖饥饿条件下解剖烟草BY-2细胞中的自噬
7. Folimycin (concanamycin A) and Bafilomycin A1, Inhibitors Specific for V-ATPase, Exert Similar but Distinct Effects on Intracellular Translocation and Processing of Glycoproteins [O] . Makoto Muroi, Nobue Shiragami, Kenji Nagao, 1994

机译：叶霉素（Cancanamycin A）和Bafilomycin A1，对V-ATP酶特异的抑制剂，对糖蛋白的细胞内易位和加工产生类似但不同的影响

The V-ATPase inhibitors concanamycin A and bafilomycin A lead to Golgi swelling in tobacco BY-2 cells

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