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首页> 外文期刊>Protoplasma: An International Journal of Cell Biology >Annexins: putative linkers in dynamic membrane-cytoskeleton interactions in plant cells
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Annexins: putative linkers in dynamic membrane-cytoskeleton interactions in plant cells

机译：Annexins：植物细胞中动态膜-细胞骨架相互作用的推定接头

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The plasma membrane, the most external cellular structure, is at the forefront between the plant cell and its environment. Hence, it is naturally adapted to function in detection of external signals, their transduction throughout the cell, and finally, in cell reactions. Membrane lipids and the cytoskeleton, once regarded as simple and static structures, have recently been recognized as significant players in signal transduction. Proteins involved in signal detection and transduction are organised in specific domains at the plasma membrane. Their aggregation allows to bring together and orient the downstream and upstream members of signalling pathways. The cortical cytoskeleton provides a structural framework for rapid signal transduction from the cell periphery into the nucleus. It leads to intracellular reorganisation and wide-scale modulation of cellular metabolism which results in accumulation of newly synthesised proteins and/or secondary metabolites which, in turn, have to be distributed to the appropriate cell compartments. And again, in plant cells, the secretory vesicles that govern polar cellular transport are delivered to their target membranes by interaction with actin microfilaments. In search for factors that could govern subsequent steps of the cell response delineated above we focused on an evolutionary conserved protein family, the annexins, that bind in a calcium-dependent manner to membrane phospholipids. Annexins were proposed to regulate dynamic changes in membrane architecture and to organise the interface between secretory vesicles and the membrane. Certain proteins from this family were also identified as actin binding, making them ideal mediators in cell membrane and cytoskeleton interactions.
机译：质膜是最外部的细胞结构，位于植物细胞与其环境之间的最前沿。因此，它自然适用于检测外部信号，在整个细胞中进行信号传导以及最终在细胞反应中发挥作用。膜脂和细胞骨架曾经被认为是简单而静态的结构，最近已被认为是信号转导的重要参与者。参与信号检测和转导的蛋白质组织在质膜的特定区域中。它们的聚集使信号通路的下游和上游成员聚集在一起并定向。皮质细胞骨架为从细胞周边到细胞核的快速信号转导提供了结构框架。它导致细胞内重组和细胞代谢的大规模调节，从而导致新合成的蛋白质和/或次生代谢产物的积累，继而必须将其分布到适当的细胞区室中。再次，在植物细胞中，控制极性细胞转运的分泌性囊泡通过与肌动蛋白微丝的相互作用传递到其靶膜。在寻找可能控制上述细胞反应后续步骤的因素时，我们集中于进化保守的蛋白家族，膜联蛋白，该膜家族以钙依赖的方式与膜磷脂结合。膜联蛋白被提出来调节膜结构的动态变化，并组织分泌囊泡和膜之间的界面。来自该家族的某些蛋白质也被鉴定为肌动蛋白结合，使其成为细胞膜和细胞骨架相互作用的理想介体。

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