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首页> 外文期刊>Protoplasma: An International Journal of Cell Biology >DNA methylation and chromosomal rearrangements in reconstructed karyotypes of Hordeum vulgare L.
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DNA methylation and chromosomal rearrangements in reconstructed karyotypes of Hordeum vulgare L.

机译：大麦重组核型的DNA甲基化和染色体重排

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One standard and two reconstructed barley karyotypes were used to study the influence of chromosomal rearrangements on the distribution pattern of DNA methylation detectable at the chromosome level. Data obtained were also compared with Giemsa N-bands and high gene density regions that had been previously described. The effect of chromosomal reconstruction in barley seems to be decidedly prominent in the repositioning of genomic DNA methylation along metaphase chromosomes. In comparison to the standard karyotype, the DNA methylation pattern was found to vary not only in the reconstructed chromosomes but also in the other chromosomes of the complements not subjected to structural alterations. Moreover, differences may occur between corresponding regions of homologues. Some specific chromosomal bands, including the nucleolus-organizing regions, showed a relative constancy in the methylation pattern, but this was not the case when the two satellites were combined by translocation in chromosome 6H(5H) of line T-30. Our results suggest that epigenetic changes like DNA methylation may play an important role in the overall genome reorganization following chromosome reconstruction.
机译：使用一种标准品和两种重建的大麦核型来研究染色体重排对在染色体水平上可检测到的DNA甲基化分布模式的影响。还将获得的数据与Giemsa N波段和先前已描述的高基因密度区域进行了比较。大麦中染色体重建的作用在沿中期染色体的基因组DNA甲基化重新定位中似乎是绝对突出的。与标准核型相比，发现DNA甲基化模式不仅在重建的染色体中发生变化，而且在未发生结构改变的补体的其他染色体中也发生变化。而且，同源物的相应区域之间可能发生差异。一些特定的染色体条带，包括核仁组织区，在甲基化模式中显示出相对恒定性，但是当两个卫星通过在T-30系的6H（5H）染色体中易位而结合在一起时，情况并非如此。我们的结果表明，表观遗传学改变（如DNA甲基化）可能在染色体重建后的整体基因组重组中起重要作用。

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