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首页> 外文期刊>Protoplasma: An International Journal of Cell Biology >The very many faces of presenilins and the γ-secretase complex
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The very many faces of presenilins and the γ-secretase complex

机译：早老素和γ-分泌酶复合物的面孔很多

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摘要

Presenilin is a central, catalytic component of the γ-secretase complex which conducts intramembrane cleavage of various protein substrates. Although identified and mainly studied through its role in the development of amyloid plaques in Alzheimer disease, γ-secretase has many other important functions. The complex seems to be evolutionary conserved throughout the Metazoa, but recent findings in plants and Dictyostelium discoideum as well as in archeons suggest that its evolution and functions might be much more diversified than previously expected. In this review, a selective survey of the multitude of functions of presenilins and the γ-secretase complex is presented. Following a brief overview of γ-secretase structure, assembly and maturation, three functional aspects are analyzed: (1) the role of γ-secretase in autophagy and phagocytosis; (2) involvement of the complex in signaling related to endocytosis; and (3) control of calcium fluxes by presenilins.
机译：早老素是γ-分泌酶复合物的中心催化组分，其进行各种蛋白底物的膜内裂解。尽管已经确定并主要通过其在阿尔茨海默病中淀粉样蛋白斑形成中的作用进行了研究，但γ-分泌酶还具有许多其他重要功能。该复合物似乎在整个后生动物中都是进化保守的，但是最近在植物和盘基网柄菌以及古细菌中的发现表明，其进化和功能可能比以前预期的更加多样化。在这篇综述中，提出了对早老蛋白和γ-分泌酶复合物多种功能的选择性调查。在简要概述了γ-分泌酶的结构，组装和成熟之后，分析了三个功能方面：（1）γ-分泌酶在自噬和吞噬作用中的作用; （2）复合物参与与胞吞作用有关的信号传导; （3）早老素控制钙通量。

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