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首页> 外文期刊>Protoplasma: An International Journal of Cell Biology >Sperm guidance to the egg finds calcium at the helm
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Sperm guidance to the egg finds calcium at the helm

机译：精子对卵的引导会帮助钙

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Sperm respond to multiple cues during guidance to the egg including chemical attractants, temperature, and fluid flow. Of these, sperm chemotaxis has been studied most extensively-over 100 years-but only recently has it started to be understood at the molecular level. The long gestation in this understanding has largely been due to technical limitations that include the detection of calciumsignal dynamics in a relatively small structure-the flagellum, measurement of actual chemoattractant gradients, the fact that only subpopulations of spermrespond at any given time, and the diversity in swimming behaviors that sperm exhibit from different species. Today, measurements of flagellar calcium signals on a fast time scale, discovery of the ion channels and organelles that may regulate these signals, and better understanding and quantitation of sperm swimming behaviors involved have givenmore certainty to our understanding of spermdirectional swimming and its control by characteristic, calcium-directed asymmetric flagellar bends. Future research will need to apply these technical advances to other forms of sperm guidance such as thermotaxis and rheotaxis as well as gaining an understanding of how the flagellar apparatus is controlled by calcium.
机译：在引导卵子过程中，精子会对多种提示做出反应，包括化学引诱剂，温度和流体流动。其中，对精子趋化性的研究已经进行了100多年，但是直到最近才开始在分子水平上对其进行理解。这种理解的长期孕育在很大程度上是由于技术限制，包括在相对较小的结构中检测钙信号动力学（鞭毛），实际趋化性梯度的测量，在任何给定时间仅精子亚群都在响应以及多样性的事实。在游泳行为中，精子表现出不同的物种。如今，在快速的时间尺度上测量鞭毛钙信号，发现可能调节这些信号的离子通道和细胞器以及对所涉及的精子游动行为的更好理解和定量，使我们对确定性精子游动及其特性控制有了更多的把握。 ，钙定向的不对称鞭毛弯曲。未来的研究将需要将这些技术进步应用于其他形式的精子指导，例如热趋和流变，以及获得对鞭毛器如何通过钙控制的理解。

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