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首页> 外文期刊>Protoplasma: An International Journal of Cell Biology >Comparative analysis of transcription factor gene families from Papaver somniferum: identification of regulatory factors involved in benzylisoquinoline alkaloid biosynthesis
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Comparative analysis of transcription factor gene families from Papaver somniferum: identification of regulatory factors involved in benzylisoquinoline alkaloid biosynthesis

机译：罂粟转录因子基因家族的比较分析：苄基异喹啉生物碱生物合成中涉及的调控因子的鉴定

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摘要

Opium poppy (Papaver somniferum L.), known for biosynthesis of several therapeutically important benzylisoquinoline alkaloids (BIAs), has emerged as the premier organism to study plant alkaloid metabolism. The most prominent molecules produced in opium poppy include narcotic analgesic morphine, the cough suppressant codeine, the muscle relaxant papaverine and the anti-microbial agent sanguinarine and berberine. Despite several health benefits, biosynthesis of some of these molecules is very low due to tight temporal and spatial regulation of the genes committed to their biosynthesis. Transcription factors, one of the prime regulators of secondary plant product biosynthesis, might be involved in controlled biosynthesis of BIAs in P. somniferum. In this study, identification of members of different transcription factor gene families using transcriptome datasets of 10 cultivars of P. somniferum with distinct chemoprofile has been carried out. Analysis suggests that most represented transcription factor gene family in all the poppy cultivars is WRKY. Comparative transcriptome analysis revealed differential expression pattern of the members of a set of transcription factor gene families among 10 cultivars. Through analysis, two members of WRKY and one member of C3H gene family were identified as potential candidates which might regulate thebaine and papaverine biosynthesis, respectively, in poppy.
机译：鸦片罂粟（Papaver somniferum L.）以生物合成几种治疗上重要的苄基异喹啉生物碱（BIAs）而闻名，现已成为研究植物生物碱代谢的主要生物。罂粟中产生的最突出的分子包括麻醉性止痛吗啡，止咳可待因，肌肉松弛药罂粟碱以及抗微生物剂血红素和小ine碱。尽管有一些健康益处，但是由于致力于其生物合成的基因在时间和空间上的严格调节，因此其中某些分子的生物合成非常低。转录因子是植物次生生物合成的主要调节因子之一，可能参与了P. somniferum中BIAs的受控生物合成。在这项研究中，使用具有不同化学特征的10个夜蛾体育品种的转录组数据集进行了不同转录因子基因家族成员的鉴定。分析表明，在所有罂粟品种中，最具代表性的转录因子基因家族是WRKY。比较转录组分析揭示了10个品种中一组转录因子基因家族成员的差异表达模式。通过分析，确定了WRKY的两个成员和C3H基因家族的一个成员可能分别调节罂粟中蒂巴因和罂粟碱的生物合成。

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