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首页> 外文期刊>Protoplasma: An International Journal of Cell Biology >Coenzyme Q(10) and its putative role in the ageing process
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Coenzyme Q(10) and its putative role in the ageing process

机译：辅酶Q（10）及其在衰老过程中的假定作用

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A phenomenon associated with the aging process is a general age-dependent decline in cellular bioenergetic capacity that varies from tissue to tissue and even from cell to cell within the same tissue. This variation eventually forms a tissue bioenergy mosaic. Recent evidence by our group suggests that the accumulation of mitochondrial DNA mutations, in conjunction with a concurrent decrease in full-length mtDNA in tissues such as skeletal and cardiac muscle, strongly correlates with decreased mitochondrial function and accounts for the bioenergy mosaic. Evidence is also presented suggesting that amelioration with coenzyme Q(10) may restore some of the age-associated decline in bioenergy function, in effect providing the potential for a "redox therapy". Coenzyme Q is a naturally occurring material that is present in the membranes of all animal cells. Its primary function is to act as an electron carrier in the mitochondrial electron transport chain enabling the energy from substrates such as fats and sugars (in the form of reducing equivalents) to be ultimately captured in the form of ATP. which in turn may be utilised as a source of cellular bioenergy. Coenzyme Q(10) has no known toxic effects and has been used in a limited number of animal studies and human clinical trials: however, the mechanism of action of coenzyme Q(10) remains unclear. A series of experiments by this group aimed at determining the efficacy of coenzyme Q(10) treatment on ameliorating the bioenergy capacity at the organ and cellular level will also be reviewed. [References: 51]
机译：与衰老过程相关的现象是细胞生物能的一般年龄依赖性下降，该生物能随着组织的变化而变化，甚至在同一组织内的细胞与细胞之间也不同。这种变化最终形成组织生物能镶嵌。我们小组的最新证据表明，线粒体DNA突变的积累，以及同时存在于骨骼和心肌等组织中的全长mtDNA的减少，与线粒体功能的下降密切相关，并说明了生物能源的镶嵌。还提供了证据表明辅酶Q（10）的改善可能会恢复一些与年龄相关的生物能功能下降，从而有效地提供了“氧化还原疗法”的潜力。辅酶Q是天然存在的物质，存在于所有动物细胞的膜中。它的主要功能是充当线粒体电子传输链中的电子载体，使来自脂肪和糖等底物的能量（以还原当量的形式）最终以ATP的形式被捕获。进而可以用作细胞生物能源的来源。辅酶Q（10）没有已知的毒性作用，并且已在有限的动物研究和人类临床试验中使用：但是，辅酶Q（10）的作用机理仍不清楚。该小组的一系列实验旨在确定辅酶Q（10）处理对改善器官和细胞水平的生物能能力的功效。 [参考：51]

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