Production,Isolation and Strcuture Determiantion of Novel Fluoroindolocarbazoles from Saccharothrix aerocolonigenes ATCC 39243

Kin Sing Lam; Daniel R.Schroeder; Jacqueline M.Veitch; Kimberly L.Colson; James A.Matson; William C.Rose

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Production,Isolation and Strcuture Determiantion of Novel Fluoroindolocarbazoles from Saccharothrix aerocolonigenes ATCC 39243

机译：嗜糖气单胞菌ATCC 39243的新型氟吲哚并咔唑的生产，分离及结构测定

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Saccharothrix aerocolonigenes ATCC 39243 produces an indolocarbazole antitumor agent rebeccamycin under. submerged fermentation conditions. Adding DL-6-fluorotryptophan to culture of S. aerocolonigenes ATCC 39243 induces the formation of two novel indolocarbazoles, fluoroindolocarbazoles A and B. Feeding DL-5-fluorotryptophan to culture of S. aerocolonigenes ATCC 39243 induces the production of a novel indolocarbazole, fluoroindolocarbazole C. These fluoroindolocarbazoles have been isolated from culture broth and purified to homogeneity by vacuum liquid chromatography and column chromatography; All three fluoroindolocarbazoles are more potent than rebeccamycin against P388 leukemia by ip route in murine model.

机译：拟糖单胞菌属产气链球菌ATCC 39243产生吲哚并咔唑类抗肿瘤药瑞贝卡霉素。淹没的发酵条件。将DL-6-氟色氨酸添加到嗜气链球菌ATCC 39243的培养物中诱导了两种新型吲哚并咔唑A和B的形成这些氟吲哚并咔唑已经从培养液中分离出来，并通过真空液相色谱和柱色谱纯化至均质。在鼠模型中，通过ip途径，所有三种氟吲哚并咔唑均比瑞贝卡霉素对P388白血病更有效。

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《The Journal of Antibiotics: An International Journal》 |2001年第1期|共9页
作者
Kin Sing Lam; Daniel R.Schroeder; Jacqueline M.Veitch; Kimberly L.Colson; James A.Matson; William C.Rose;
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中图分类药学;药品;
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1. Production,Isolation and Strcuture Determiantion of Novel Fluoroindolocarbazoles from Saccharothrix aerocolonigenes ATCC 39243 [J] . Kin Sing Lam, Daniel R.Schroeder, Jacqueline M.Veitch, The Journal of Antibiotics: An International Journal . 2001,第1期

机译：嗜糖气单胞菌ATCC 39243的新型氟吲哚并咔唑的生产，分离及结构测定
2. Molecular Analysis of the Rebeccamycin l-Amino Acid Oxidase from Lechevalieria aerocolonigenes ATCC 39243 [J] . Tomoyasu Nishizawa, Courtney C. Aldrich, David H. Sherman Journal of bacteriology . 2005,第6期

机译：产气杆状假单胞菌ATCC 39243的Rebeccamycin l-氨基酸氧化酶的分子分析
3. Lechevalieria aerocolonigenes ATCC39243 のレベッカマイシン生合成遺伝子群の解析 [J] . 尾仲宏康, 谷口真市, 五十嵐康弘, 日本農芸化学会誌 . 2004,第9期

机译：产气单胞菌假单胞菌ATCC39243的雷贝卡霉素生物合成基因分析
4. Analysis of Cellulase Activity of Mixed Bacteria and Production of Butanol by Co-Cultured Mixed Bacteria and Clostridium Acetobutylicum ATCC824 [C] . Cui-Ying Hu, Dong-Xue Hu, Lin-Mei Fu, International Conference on New Energy and Sustainable Development . 2017

机译：共培养混合细菌及丁醇纤维素纤维素酶活性分析及丁醇苯乙烯基丁基丁基菌ATCC824
5. Isolation and characterization of the [NAD(P)-independent] polyol dehydrogenase from the plasma-membranes of Gluconobacter oxydans ATCC strain 621. [D] . VanLare, Ian Judd. 1997

机译：从氧化葡糖杆菌ATCC菌株621的血浆膜中分离[NAD（P）-不依赖的]多元醇脱氢酶并进行表征。
6. Molecular Analysis of the Rebeccamycin l-Amino Acid Oxidase from Lechevalieria aerocolonigenes ATCC 39243 [O] . Tomoyasu Nishizawa, Courtney C. Aldrich, David H. Sherman 2005

机译：产气杆状假单胞菌ATCC 39243的Rebeccamycin l-氨基酸氧化酶的分子分析
7. Production, Isolation and Structure Determination of Novel Fluoroindolocarbazoles from Saccharothrix aerocolonigenes ATCC 39243. [O] . KIN SING LAM, DANIEL R. SCHROEDER, JACQUELINE M. VEITCH, 2001

机译：Saccharothrix Aerocologenes ATCC 39243的生产，分离和结构测定新氟吲哚唑胺。

Production,Isolation and Strcuture Determiantion of Novel Fluoroindolocarbazoles from Saccharothrix aerocolonigenes ATCC 39243

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