FR198248, a New Anti-influenza Agent Isolated from Aspergillus terreus No.13830 I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities

Yutaka Nishihara; Eisaku Tsujii; Yukiko Yamagishi; Kazutoshi Sakamoto; Yasuhisa Tsurumi; Shigetada Furukawa; Reiko Ohtsu; Toru Kino; Motohiro Hino; Seiji Hashimoto; Michio Yamashita

首页> 外文期刊>The Journal of Antibiotics: An International Journal >FR198248, a New Anti-influenza Agent Isolated from Aspergillus terreus No.13830 I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities

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FR198248, a New Anti-influenza Agent Isolated from Aspergillus terreus No.13830 I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities

机译：FR198248，一种从米曲霉13830分离的新型抗流感药I.分类，发酵，分离，理化性质和生物活性

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A novel anti-influenza agent, FR 198248, was isolated from th cultured broth of a fungal strain No.13830. The strain was identified as Aspergillus terreus from morphlogical characteristics. FR 198248, a new type of hydroxyl benzaldehyde compound, showed antiinflenza virus activity in Madin-Darby canine kidney (MDCK) cells in vitro. The mode of action of FR 198248 against influenza virus A could be ascribed to an inhibitory effect of the stage of virus adsorption. Furthermore, FR 198248 possessed potent in vivo anti-influenza activity in a murine model of respiratory tract infection.

机译：从真菌菌株13830的培养液中分离了新型抗流感药FR 198248。根据形态特征将该菌株鉴定为土曲霉。 FR 198248是一种新型的羟基苯甲醛化合物，在体外Madin-Darby犬肾（MDCK）细胞中显示抗流感病毒活性。 FR 198248对流感病毒A的作用方式可归因于病毒吸附阶段的抑制作用。此外，FR 198248在小鼠呼吸道感染模型中具有有效的体内抗流感活性。

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《The Journal of Antibiotics: An International Journal》 |2001年第2期|共8页
作者
Yutaka Nishihara; Eisaku Tsujii; Yukiko Yamagishi; Kazutoshi Sakamoto; Yasuhisa Tsurumi; Shigetada Furukawa; Reiko Ohtsu; Toru Kino; Motohiro Hino; Seiji Hashimoto; Michio Yamashita;
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正文语种 eng
中图分类药学;药品;
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1. FR198248, a New Anti-influenza Agent Isolated from Aspergillus terreus No.13830 I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities [J] . Yutaka Nishihara, Eisaku Tsujii, Yukiko Yamagishi, The Journal of Antibiotics: An International Journal . 2001,第2期

机译：FR198248，一种从米曲霉13830分离的新型抗流感药I.分类，发酵，分离，理化性质和生物活性
2. FR252921, a Novel Immunosuppressive Agent Isolated from Pseudomonas fluorescens No. 408813: II Taxonomy, Fermentation, Isolation, Isolation, Physico-chemical Properties and Biological Activities of FR252921, FR252922 and FR256523 [J] . Kiyotaka Fujine, Miho Tanaka, Keisuke Ohsumi, The Journal of Antibiotics: An International Journal . 2003,第2期

机译：FR252921，一种从荧光假单胞菌（Pseudomonas fluorescens）编号408813分离的新型免疫抑制剂：FR252921，FR252922和FR256523的II分类，发酵，分离，分离，理化性质和生物学活性
3. Terreulactones A, B, C, and D: Novel Acetylcholinesterase Inhibitors Produced by Aspergillus terreus I. Taxonomy, Fermentation, Isolation and Biological Activities [J] . Kyung-Mi Cho, Won-Gon Kim, Chong-Kil Lee, The Journal of Antibiotics: An International Journal . 2003,第4期

机译：地雷内酯A，B，C和D：土曲霉产生的新型乙酰胆碱酯酶抑制剂I.分类，发酵，分离和生物学活性
4. Effects of Different Complexing Agents on the Photocatalytic Activities and Physico-chemical Properties of Photocatalytic Materials La2NiCrO6 [C] . Xin Wang, Ruisheng Hu, Xue Li, 2013 International conference on materials for renewable energy amp; environment . 2013

机译：不同络合剂对La2NiCrO6光催化材料光催化活性和理化性能的影响
5. Investigation of higher plants for potential antiinfective agents: Part I. Isolation and antimicrobial activity of fusaric acid and dehydrofusaric acid from Fusarium oxysporum and Part II. Isolation and structure elucidation of components of Baphia nitida Lodd and Part III. Evaluation of higher plant constituents in a novel assay for the potential inhibition of phenoloxidase in Cryptococcus neoformans. [D] . Hatch, Deanna Mari. 1995

机译：高等植物潜在抗感染药的研究：第一部分。尖孢镰刀菌中富马酸和脱氢富马酸的分离和抑菌活性，第二部分。楠（Baphia nitida Lodd）和第三部分的成分的分离和结构解析。在新型测定中评估新型隐球菌中酚氧化酶的潜在抑制作用。
6. Isolation chemical structure acute toxicity and some physicochemical properties of territrem B from Aspergillus terreus. [O] . F C Peng, K H Ling, Y Wang, 1985

机译：曲霉曲霉B的分离化学结构急性毒性和一些理化性质。
7. FR198248, a New Anti-influenza Agent Isolated from Aspergillus terreus No.13830. I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities. [O] . YUTAKA NISHIHARA, EISAKU TSUJII, YUKIKO YAMAGISHI, 2001

机译：FR198248是一种从Aspergillus Terreus No.13830中分离的新的抗流感剂。 I.分类法，发酵，分离，物理化学性质和生物活性。

FR198248, a New Anti-influenza Agent Isolated from Aspergillus terreus No.13830 I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities

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