Formatio of Anion-selective Membrane Pores by Texenomycin A, A Basic Lipopeptaibol Antibiotic

P. A. Grigoriev; A. Berg; B. Schlegel; S. Heinze; U. Grafe

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Formatio of Anion-selective Membrane Pores by Texenomycin A, A Basic Lipopeptaibol Antibiotic

机译：碱性脂环素抗生素Texenomycin A对阴离子选择性膜孔的形成

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Peptaibols are fungal linear peptides that own their biological activities to the formation of ion-penetrable pores within biological membranes. Our previous investigations suggested that the constituting amino acids determine channel stability, ion selectivity and biological activities. Lipopeptaibol antibiotics such as texenomycin A (1, fig. 1) are distinguishable from the common peptaibols due to acylation of the N-terminus by a long-chain fatty acid and substitution of the carbon terminus by amino or guanidino moieties.

机译：肽醇是真菌线性肽，其具有其生物活性以在生物膜内形成可离子渗透的孔。我们以前的研究表明，组成氨基酸决定通道稳定性，离子选择性和生物活性。脂肽醇抗生素，如特松霉素A（图1），与普通的肽醇区分开来，这是由于N端被长链脂肪酸酰化并碳端被氨基或胍基部分取代。

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《The Journal of Antibiotics: An International Journal》 |2002年第9期|共3页
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P. A. Grigoriev; A. Berg; B. Schlegel; S. Heinze; U. Grafe;
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正文语种 eng
中图分类药学;药品;
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1. Formatio of Anion-selective Membrane Pores by Texenomycin A, A Basic Lipopeptaibol Antibiotic [J] . P. A. Grigoriev, A. Berg, B. Schlegel, The Journal of Antibiotics: An International Journal . 2002,第9期

机译：碱性脂环素抗生素Texenomycin A对阴离子选择性膜孔的形成
2. Main-chain length control of conformation, membrane activity, and antibiotic properties of lipopeptaibol sequential analogues [J] . Oancea S, Hilma G, Peggion C, Chemistry & biodiversity . 2008,第5期

机译：脂肽醇顺序类似物的构象，膜活性和抗生素特性的主链长度控制
3. Short-chain analogues of the lipopeptaibol antibiotic trichogin GA IV: conformational analysis and membrane modifying properties [J] . Fernando Formaggio Cristina Peggion Marco Crisma and Claudio Toniolo Journal of the Chemical Society, Perkin Transactions 2 . 2001,第8期

机译：脂肽醇抗生素trichogin GA IV的短链类似物：构象分析和膜修饰性质
4. Pulsed ESR Study of the Topology and Dynamics of a Spin-Labeled Lipopeptaibol Antibiotic In a Lipid Membrane [C] . Victoria N. Syryamina, Nicolay P. Isaev, Marta De Zotti American Peptide Symposium . 2011

机译：脉冲ESR研究脂膜中旋转标记的脂肪肽抗生素的拓扑和动力学
5. Effect of Pore Geometry on Membrane Flux Decline due to Pore Constriction by Particles in Ultra and Micro Filtration. [D] . Faghihi, Mohammad Hosein. 2013

机译：在超滤和微滤中，孔的几何形状对膜的通量下降的影响是由于颗粒的孔收缩。
6. The Anion-Selective Pore of the Bestrophins a Family of Chloride Channels Associated with Retinal Degeneration [O] . Zhiqiang Qu, Li-Ting Chien, Yuanyuan Cui, 2006

机译：Bestrophins与视网膜变性相关的氯离子通道家族的阴离子选择孔。
7. Probing membrane permeabilization by the antibiotic lipopeptaibol trichogin GA IV in a tethered bilayer lipid membrane [O] . L. Becucci, F. Maran, R. Guidelli 2012

机译：在束缚的双层脂质膜中通过抗生素脂肽天花粉蛋白GA IV探测膜通透性

Formatio of Anion-selective Membrane Pores by Texenomycin A, A Basic Lipopeptaibol Antibiotic

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