A Novel Erythromycin, 6-Desmethyl Ertyromycin D, Made by Substituting an Acyltransferase Domain of the Erythromycin Polyketide Synthase

Hrvoje Petkovic; rachel E.Lill; Rose M.Sheridan; Barrie Wilkinson; Ellen L.McCormick; Hamish A.I.McArthur; James Staunton; Peter F.Leadlay; Steven G.Kendrew

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A Novel Erythromycin, 6-Desmethyl Ertyromycin D, Made by Substituting an Acyltransferase Domain of the Erythromycin Polyketide Synthase

机译：通过取代红霉素聚酮化合物合酶的酰基转移酶结构域制备的新型红霉素6-去甲基酪氨酸霉素D

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The acyltransferase (AT) domain in module 4 of the erythromycin polyketide synthase (PKS) was substituted wtih an AT domain from the rapamycin PKS module 2 in order to alter the substrate specificity from methylmalonyl-CoA to malonyl-CoA. The resulting strain produced 6-desmethyl erythromycin D as the predominant product. This AT domain swap completes the library of malonyl-CoA AT swaps on the erythromycin PKS and reinforces PKS engineering as a robust and generic tool.

机译：用雷帕霉素PKS模块2的AT结构域取代红霉素聚酮化合物合酶（PKS）模块4中的酰基转移酶（AT）结构域，以将底物特异性从甲基丙二酰辅酶A转变为丙二酰辅酶A。所得菌株产生6-去甲基红霉素D作为主要产物。该AT域交换完善了红霉素PKS上的丙二酰辅酶A AT交换库，并加强了PKS工程，使其成为一个强大而通用的工具。

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《The Journal of Antibiotics: An International Journal》 |2003年第6期|共9页
作者
Hrvoje Petkovic; rachel E.Lill; Rose M.Sheridan; Barrie Wilkinson; Ellen L.McCormick; Hamish A.I.McArthur; James Staunton; Peter F.Leadlay; Steven G.Kendrew;
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正文语种 eng
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1. A Novel Erythromycin, 6-Desmethyl Ertyromycin D, Made by Substituting an Acyltransferase Domain of the Erythromycin Polyketide Synthase [J] . Hrvoje Petkovic, rachel E.Lill, Rose M.Sheridan, The Journal of Antibiotics: An International Journal . 2003,第6期

机译：通过取代红霉素聚酮化合物合酶的酰基转移酶结构域制备的新型红霉素6-去甲基酪氨酸霉素D
2. Functional orientation of the acyltransferase domain in a module of the erythromycin polyketide synthase [J] . Gokhale RS., Cane DE., Khosla C., Biochemistry . 1998,第8期

机译：酰基转移酶结构域在红霉素聚酮合酶模块中的功能定位
3. The loading domain of the erythromycin polyketide synthase is not essential for erythromycin biosynthesis in Saccharopolyspora erythraea [J] . Ana Pereda, Richard G. Summers, Diane L. Stassi, Microbiology . 1998,第2期

机译：红霉素聚酮合成酶的加载结构域对Saccharopolyspora ererthraea中的红霉素生物合成而不是必需的
4. Comparative study of oral administration of Sacha Inchi oil extraction with erythromycin versus oral erythromycin on the treatment of Acne Vulgaris [C] . Piraphol Suthiphasil, Jarasphol Rintha, Thamthiwat Nararatwanchai, International Conference on Digital Arts, Media and Technology . 2018

机译：红霉素与口服红霉素口服佐茶印加油提取物治疗寻常型痤疮的比较研究
5. Enzymatic and structural study of domains and modules from erythromycin and picromycin polyketide synthases. [D] . Lu, Hongxiang. 2003

机译：对红霉素和青霉素聚酮化合物合酶的结构域和模块的酶促和结构研究。
6. Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives. [O] . X Ruan, A Pereda, D L Stassi, 1997

机译：红霉素聚酮合酶中的酰基转移酶结构域取代产生新的红霉素衍生物。
7. Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives. [O] . Ruan, X, Pereda, A, Stassi, D L, 1997

机译：红霉素聚酮合酶中的酰基转移酶结构域取代产生新的红霉素衍生物。

A Novel Erythromycin, 6-Desmethyl Ertyromycin D, Made by Substituting an Acyltransferase Domain of the Erythromycin Polyketide Synthase

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