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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Isolation and structure of a new macrolide antibiotic, erythromycin G and a related biosynthetic intermediate from a culture of saccharopolyspora erythraea
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Isolation and structure of a new macrolide antibiotic, erythromycin G and a related biosynthetic intermediate from a culture of saccharopolyspora erythraea

机译：一种新的大环内酯类抗生素红霉素G及其相关生物合成中间体的分离和结构

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摘要

The new naturally occurring erythromycin G (4), formally derived from erythromycin B by hydroxylation of the C-16 methyl group, and 3-O-mycarosylerythronolide B (5), an erythromycin biosynthetic intermediarte previously obtained only from microorganisms blocked in erythromycin biosynthesis, were isolated from a concentrate of mother liquors derived from a culture of Saccharopolyspora erythraea. The structure of erythromycin G was defined by spectroscopic data and X-ray crystallographic analysis. Theoretical calculation of 4 has been performed at MM2 level, and the low-energy conformations has been compared with X-ray data: both theoretical and experimental approaches give similar three-dimensional shapes. Antibacterial activity of 4 against both Gram-positive and Gram-negative organisms has been evaluated. A simple method for the isolation of large amounts of erythromycins B(2) and D is provided as well.
机译：新的天然红霉素G（4），其通过C-16甲基的羟基化而正式衍生自红霉素B和3-O-myososylerythronolide B（5），一种以前仅从红霉素生物合成中受阻的微生物获得的红霉素生物合成中间体，分离自浓缩的红曲糖培养物母液。红霉素G的结构通过光谱数据和X射线晶体学分析确定。 4的理论计算已在MM2级别进行，并且低能构象已与X射线数据进行了比较：理论和实验方法都给出了相似的三维形状。已经评估了4对革兰氏阳性和革兰氏阴性生物的抗菌活性。还提供了一种用于分离大量红霉素B（2）和D的简单方法。

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