Orthogonal Protein Interactions in Spore Pigment Producing and Antibiotic Producing Polyketide Syntheses

Taek Soon Lee; Chaitan Khosla; Yi Tang

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Orthogonal Protein Interactions in Spore Pigment Producing and Antibiotic Producing Polyketide Syntheses

机译：孢子色素生产和抗生素生产聚酮化合物合成中的正交蛋白质相互作用

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The actinomycetes produce antibiotics as well as spore pigments during their life cycle by using Type II polyketide synthases(PKSs).Each PKS minimally consists of a ketosynthase heterodimer and an acyl carrier protein.The acyl carrier protein has been shown to be interchangeable among different antibiotic producing Type II PKSs.Surprisingly,we have discovered a fundamental incompatibility between the ketosynthases and acyl carrier proteins from antibiotic producing pathways and those from spore pigment pathways.Although antibiotic PKSs can interact with acyl carrier proteins from spore pigment pathways,spore pigment PKSs are unable to recognize acyl carrier proteins from polyketide antibiotic pathways.This observation provides an insight into a critical mechanism by which natural product biosynthetic specificity is exercised by members of this bacterial family.

机译：放线菌通过使用II型聚酮化合物合酶（PKSs）在其生命周期中产生抗生素和孢子色素，每个PKS最少由酮合酶异二聚体和酰基载体蛋白组成，已证明酰基载体蛋白可在不同抗生素之间互换令人惊讶的是，我们发现了来自细菌生产途径的酮基合酶与酰基载体蛋白和来自孢子色素途径的酰基载体蛋白之间存在根本的不相容性。尽管抗生素PKS可以与来自孢子色素途径的酰基载体蛋白相互作用，但孢子色素PKS无法可以识别来自聚酮化合物抗生素途径的酰基载体蛋白。该观察结果提供了对该细菌家族成员行使天然产物生物合成特异性的关键机制的见解。

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《The Journal of Antibiotics: An International Journal》 |2005年第10期|共4页
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Taek Soon Lee; Chaitan Khosla; Yi Tang;
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正文语种 eng
中图分类药学;
关键词
polyketide synthase; ketosynthase; acyl carrier protein; spore pigment; antibiotic;

机译：聚酮化合物合酶酮合酶酰基载体蛋白孢子色素抗生素;

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1. Orthogonal Protein Interactions in Spore Pigment Producing and Antibiotic Producing Polyketide Syntheses [J] . Taek Soon Lee, Chaitan Khosla, Yi Tang The Journal of Antibiotics: An International Journal . 2005,第10期

机译：孢子色素生产和抗生素生产聚酮化合物合成中的正交蛋白质相互作用
2. Insights into polyketide biosynthesis gained from repurposing antibiotic-producing polyketide synthases to produce fuels and chemicals [J] . Yuzawa Satoshi, Keasling Jay D., Katz Leonard The Journal of Antibiotics: An International Journal . 2016,第7期

机译：洞察含有重新施用抗生素的聚酮合成酶的聚酮化合物生物合成酶以产生燃料和化学物质
3. Intermodular communication in polyketide syntheses: Comparing the role ofprotein-protein interactions to those in other multidomain proteins [J] . Tsuji SY, Wu N, Khosla C Biochemistry . 2001,第8期

机译：聚酮化合成中的混合物通信：比较蛋白质 - 蛋白质相互作用对其他多麦片蛋白的作用
4. The Trichoderma-plant interaction is mediated by avirulence proteins produced by this fungus [C] . International Workshop on Trichoderma and Gliocladium; ; . 2004

机译：木霉-植物相互作用是由这种真菌产生的无毒蛋白介导的
5. The protein and peptide mediated syntheses of non-biologically-produced oxide materials. [D] . Dickerson, Matthew B. 2008

机译：非生物产生的氧化物材料的蛋白质和肽介导的合成。
6. Interactions between antibiotic-producing and non-producing staphylococci in skin surface and sub-surface models. [O] . W. C. Noble, J. A. Willie 1980

机译：皮肤表面和亚表面模型中抗生素产生和不产生葡萄球菌之间的相互作用。
7. Orthogonal Protein Interactions in Spore Pigment Producing and Antibiotic Producing Polyketide Synthases [O] . Taek Soon Lee, Chaitan Khosla, Yi Tang 2005

机译：孢子颜料生产和抗生素生产聚酮合成酶的正交蛋白质相互作用
8. Interaction between DNA and Alpha/Beta-Type Small, Acid-Soluble Spore Proteins: ANew Class of DNA-Binding Protein [R] . Setlow, B., Sun, D., Setlow, P. 1992

机译：DNa与α/β型小型酸溶性孢子蛋白之间的相互作用：一类DNa结合蛋白

Orthogonal Protein Interactions in Spore Pigment Producing and Antibiotic Producing Polyketide Syntheses

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