The Structures of Fluostatins C,D and E,Novel Members of the Fluostatin Family

Kathrin Schneider; Graeme Nicholson; Markus Strobele; Stephanie Baur; Jorg Niehaus

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The Structures of Fluostatins C,D and E,Novel Members of the Fluostatin Family

机译：氟他汀C，D和E的结构，氟他汀家族的新成员

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Three new fluostatin antibiotics have been isolated from the culture filtrate of Streptomyces strain Acta 1383.The chemical structures of these compounds were determined by mass spectrometry and NMR spectroscopy.The relative configuration has been determined by X-ray crystal structure analysis and the absolute configuration was deduced from NMR data with the help of Helmchen esters.These compounds represent the first reported epoxide fluostatins(1,2)and underline previously found analogies to the group of kinamycin antibiotics.

机译：从链霉菌Acta 1383菌株的培养滤液中分离出三种新的氟司他丁抗生素，分别通过质谱和NMR光谱法测定了这些化合物的化学结构，通过X射线晶体结构分析确定了其相对构型，其绝对构型为借助Helmchen酯从NMR数据推导得出这些化合物代表了第一个报道的环氧化物fluostatins（1,2），并强调了以前发现的与卡那霉素类抗生素相似的化合物。

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《The Journal of Antibiotics: An International Journal》 |2006年第2期|共5页
作者
Kathrin Schneider; Graeme Nicholson; Markus Strobele; Stephanie Baur; Jorg Niehaus;
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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
fluostatin; kinarnycin; structure elucidation;

机译：氟他汀;金霉素;结构解析;

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1. The Structures of Fluostatins C,D and E,Novel Members of the Fluostatin Family [J] . Kathrin Schneider, Graeme Nicholson, Markus Strobele, The Journal of Antibiotics: An International Journal . 2006,第2期

机译：氟他汀C，D和E的结构，氟他汀家族的新成员
2. Fluostatins C～E,Novel Members of the Fluostatin Family Produced by Streptomyces Strain Acta 1383 [J] . Stefanie Baur, Jorg Niehaus, Amalia D.Karagouni The Journal of Antibiotics: An International Journal . 2006,第5期

机译：链霉菌菌株Acta 1383生产的Fluostatins C〜E，Fluostatin家族的新成员
3. Fluostatins A and B, new inhibitors of dipeptidyl peptidase III, produced by Streptomyces sp. TA-3391 - II. Structure determination [J] . Akiyama T., Takahashi Y., Naganawa H., The Journal of Antibiotics: An International Journal . 1998,第6期

机译：Fluostatins A和B是由链霉菌属（Streptomyces sp。）生产的二肽基肽酶III的新抑制剂。 TA-3391-II。结构确定
4. Designing for Dynamic Family Structures: Divorced Families and Interactive Systems [C] . William Odom, John Zimmerman, Jodi Forlizzi 8th ACM conference on designing interactive systems 2010 . 2010

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5. Family structures as predictors of attachment security: The relationship between parental attachment security and romantic attachment security in stepfamilies and intact families. [D] . Stanish, Natalie A. 2016

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6. Understand the Specific Regio- and Enantioselectivity of Fluostatin Conjugation in the Post-Biosynthesis [O] . Yuanqi Wang, Changsheng Zhang, Yi-Lei Zhao, 2020

机译：了解后生物合成中的氟他汀缀合的特定区域和对映体选择性。
7. Fluostatins M–Q Featuring a 6-5-6-6 Ring Skeleton and High Oxidized A-Rings from Marine Streptomyces sp. PKU-MA00045 [O] . Jing Jin, Xiaoyan Yang, Tan Liu, 2018

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The Structures of Fluostatins C,D and E,Novel Members of the Fluostatin Family

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